The comparison of inflammatory markers in pentylenetetrazole-induced acute epileptic seizure model and chronic epilepsy model in rats

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dc.contributor.authorTaşkıran, Ahmet Şevki
dc.contributor.authorTaştemur, Yaşar
dc.date.accessioned2024-10-26T17:34:08Z
dc.date.available2024-10-26T17:34:08Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractRecent studies have provided important evidence that neuroinflammation has an effective role in epilepsy pathophysiology. However, it is not clear that the occurrence of neuroinflammation is related to one epileptic seizure or repeating seizures. Therefore, we aimed to investigate the comparison of inflammatory markers in pentylenetetrazole-induced acute epileptic seizure model and chronic epilepsy model in rats. In this study, 18 male Wistar albino rats were used. The animals divided into three groups as control, acute epileptic seizure model and chronic epilepsy model. Inflammatory markers (TNF-?, IL-1 ?, COX-1, and COX-2) were measured by using ELISA methods in the cortical and hippocampal brain regions after completing the epileptic model procedure. Statistical evaluation of the data was performed by one-way ANOVA and multiple comparisons were determined by the Tukey test. Statistical significance was defined at p<0.05. Obtained data show that there was significant increase in inflamattory markers in chronic epilepsy model compared to the control and acute epileptic seizure model (p<0.05). In conlusion, this study may suggest that inflammatory sytem is related to epileptogenesis process rather than only one epileptic seizure.
dc.identifier.doi10.17776/csj.735457
dc.identifier.endpage641
dc.identifier.issn2587-2680
dc.identifier.issn2587-246X
dc.identifier.issue3
dc.identifier.startpage635
dc.identifier.trdizinid456578
dc.identifier.urihttps://doi.org/10.17776/csj.735457
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/456578
dc.identifier.urihttps://hdl.handle.net/20.500.12418/23544
dc.identifier.volume41
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofCumhuriyet Science Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleThe comparison of inflammatory markers in pentylenetetrazole-induced acute epileptic seizure model and chronic epilepsy model in rats
dc.typeArticle

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