Effects of Rhodiola rosea on indomethacin-induced gastric injury

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dc.contributor.authorOkkay, Irmak Ferah
dc.contributor.authorOkkay, Ufuk
dc.contributor.authorKarataş, Özhan
dc.date.accessioned2024-10-26T17:44:11Z
dc.date.available2024-10-26T17:44:11Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: The objective of the present study was to evaluate the effects of Rhodiola rosea in the indomethacin-induced ulcer model in rats and to clarify the underlying mechanisms of action. Methods: Rats in treatment groups were treated with Rhodiola rosea (RR) 14 days. Peptic ulcer was induced by indomethacin (IND) injection (100 mg/kg, p.o.). The groups (n = 6) were designed as; Group I (control); Group II (IND): After 24h of food starvation, rats were given only 100 mg/kg IND by oral gavage to induce gastric mucosal injury. Group III (ESO): Rats were pretreated with 20 mg/kg of ESO for 14 consecutive days by oral gavage. Group IV (RR): Rats were pretreated with 500 mg/kg RR for 14 consecutive days with oral gavage. Results: Rhodiola rosea effectively alleviated indomethacin-induced ulcer via reduction in oxidative stress (decreased MDA and increased SOD, and GSH). Moreover, Rhodiola rosea alleviated indomethacin-induced damage by regulating expressions of COX enzymes, prostaglandin E2, proliferating cell nuclear antigen (PCNA), cell proliferation, apoptosis and regulated the NF-?B signaling pathway. Rhodiola rosea also attenuated inflammatory injury by suppressing TNF-????, IL-1?, and NF-?B. The caspase-3 expression was also down-regulated in stomach tissues. Conclusions: In conclusion, Rhodiola rosea protected the gastric mucosa from harmful effects of indomethacin and as a natural medicinal herb, Rhodiola rosea might be a potential therapeutic agent for preventing and treating indomethacin-induced gastric damage.
dc.identifier.doi10.5798/dicletip.1037590
dc.identifier.endpage739
dc.identifier.issn1300-2945
dc.identifier.issn1308-9889
dc.identifier.issue4
dc.identifier.startpage732
dc.identifier.trdizinid505396
dc.identifier.urihttps://doi.org/10.5798/dicletip.1037590
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/505396
dc.identifier.urihttps://hdl.handle.net/20.500.12418/25160
dc.identifier.volume48
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofDicle Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleEffects of Rhodiola rosea on indomethacin-induced gastric injury
dc.typeArticle

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