Effect of various irrigation solutions on cytokine expression of human gingival fibroblast: in vitro study

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dc.contributor.authorAydın, Zeliha Uğur
dc.contributor.authorAkpınar, Kerem Engin
dc.contributor.authorHepokur, Ceylan
dc.contributor.authorAlpay, Merve
dc.contributor.authorAltunbaş, Demet
dc.date.accessioned2024-10-26T17:44:09Z
dc.date.available2024-10-26T17:44:09Z
dc.date.issued2019
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractAim: The aim of this study is to investigate the release of IL-1,TNF- ? and VEGF following administration of NaOCl, propolisand chitosan solutions on human gingival fibroblasts.Materials and Methods: This study was conducted on humanfibroblast by cell culture and evaluation of the direct effectof various solutions on the cultured cells. The release ofpro-inflammatory interleukin (IL), tumor necrosis factor (TNF)? and vascular endothelial growth factor (VEGF) on fibroblastwas analyzed after administration of irrigation solutions. Logconcentrations of NaOCl, Propolis and Chitosan effects oncells were measured by colorimetric method.Results: IL-1 and TNF-? secretion levels decreased duringpropolis and chitosan applications, which are natural products.It was also found that the propolis increased VEGF secretionmore than the other materials.Conclusions: The results of this study suggest that propolisand chitosan may contribute to the recovery of periapical tissuesvia anti-inflammatory cytokines level secreted during theinflammatory process. It is important to search for the biologicaleffect of the materials in contact with the direct or indirectcause of the surrounding tissues during the endodontic treatment.
dc.identifier.doi10.5505/yeditepe.2019.96268
dc.identifier.endpage203
dc.identifier.issn2458-9586
dc.identifier.issue2
dc.identifier.startpage198
dc.identifier.trdizinid329756
dc.identifier.urihttps://doi.org/10.5505/yeditepe.2019.96268
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/329756
dc.identifier.urihttps://hdl.handle.net/20.500.12418/25134
dc.identifier.volume15
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartof7tepe Klinik
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiş Hekimliği
dc.titleEffect of various irrigation solutions on cytokine expression of human gingival fibroblast: in vitro study
dc.typeArticle

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