Evaluation of Apoptosis Markers Caspas-8, Cytochrome C Levels in PCOS Patients

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dc.contributor.authorSariakcali, Baris
dc.contributor.authorDuman, Gulhan
dc.date.accessioned2024-10-26T18:06:01Z
dc.date.available2024-10-26T18:06:01Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground: Apoptosis is defined as a programmed cell death that eliminates dysfunctional, damaged, and fulfilled cells as a result of a certain stimulus. PCOS, IR, ovarian hyperandrogenism, hyperinsulinemia, and alterations in follicular endocrine signaling may impact the activation, growth, survival, and atresia of follicles. As a result of this impact, polycystic morphology may be observed in the ovaries, follicle development may be inhibited, and anovulation may occur. Aim: We aimed to investigate the relationship between the apoptosis markers caspase-8 and cytochrome-c levels and PCOS patients. Methods: Thirty female patients diagnosed with PCOS and 30 healthy volunteers were included in the study as a control group. Caspase-8 and cytochrome-c levels were measured by ELISA method in the sera of patients and healthy volunteers. Results: 30 PCOS female patients and 30 healthy control group were included in the study. No difference was found between the caspase-8 and cytochrome-c levels of PCOS patients and the caspase-8 and cytochrome-c levels of the healthy control group. (p <0.092, p <0.473). The mean ages of the patient and control groups were similar (mean age of patients: 24, mean age of control: 25). In the patient group, there was no relationship between total testosterone and caspase-8 and cytochrome-c levels (p <0.276, p <0.291). Conclusion: In polycystic ovary patients, the values of caspase-8, the apoptosis marker involved in the extrinsic pathway, and cytochrome-c, which is involved in the intrinsic pathway, similar to the control group. In order to investigate the relationship between PCOS and apoptosis, we suggest that apoptosis markers should be examined in the follicle fluids of PCOS patients.
dc.identifier.doi10.53350/pjmhs22161574
dc.identifier.endpage578
dc.identifier.issn1996-7195
dc.identifier.issue1
dc.identifier.startpage574
dc.identifier.urihttps://doi.org/10.53350/pjmhs22161574
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29303
dc.identifier.volume16
dc.identifier.wosWOS:000754051500007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherLahore Medical Research Center Llp
dc.relation.ispartofPakistan Journal of Medical & Health Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPCOS
dc.subjectApoptosis
dc.subjectCaspase-8
dc.subjectCytochrome-C
dc.titleEvaluation of Apoptosis Markers Caspas-8, Cytochrome C Levels in PCOS Patients
dc.typeArticle

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