Curcumin Attenuates Nonylphenol-Induced Toxicity In Brain Development; An Experimental Study

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dc.contributor.authorAlisan Suna, Pinar
dc.contributor.authorOz Gergin, OZlem
dc.contributor.authorBaran, Munevver
dc.contributor.authorUlger, Menekse
dc.contributor.authorGoc, Rumeysa
dc.contributor.authorYay, Arzu
dc.date.accessioned2024-10-26T17:54:29Z
dc.date.available2024-10-26T17:54:29Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: Nonylphenol is an alkylphenol compound that has been widely used in the industry. It has endocrine-disrupting properties. The effect of alkylphenol compounds on development has been the subject of a limited number of studies. Herein, we aimed to examine curcumin's effect against nonylphenol toxicity on brain development. Methods: For this study, 30 pregnant female Wistar albino rats from the Animal Laboratory of Erciyes University, Faculty of Medicine, were used. The rats were randomly divided into the following 5 groups; the control group, corn oil group (150µl/kg/day), nonylphenol group (50µl/kg/day), curcumin group (100mg/kg/day) and curcumin+nonylphenol group (100mg/kg/day+50 µl/kg/day). After the sacrification, histological and immunohistochemical evaluations were made. Results: Histopathologically, vascular congestion, increased GFAP, and p-tau immunoreactivity intensity was found in the developing brain of the nonylphenol group. Moreover, co-treatment of nonylphenol administrated with curcumin showed slight pathological alterations with vascular congestion. Conclusions: These data suggest that nonylphenol-induced increase in GFAP and p-tau immunoreactivity contributes to toxicity caused impairment in the rat brain. Additionally, curcumin had a neuroprotective effect against nonylphenol-induced neurotoxicity. © 2023, Neurological Society R.O.C (Taiwan). All rights reserved.
dc.description.sponsorshipErciyes University Scientific Research Projects Coordination Unit, (TYL-7098)
dc.identifier.endpage107
dc.identifier.issn1028-768X
dc.identifier.issue3
dc.identifier.pmid37674420
dc.identifier.scopus2-s2.0-85169998648
dc.identifier.scopusqualityQ4
dc.identifier.startpage100
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27259
dc.identifier.volume32
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNeurological Society R.O.C (Taiwan)
dc.relation.ispartofActa Neurologica Taiwanica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectbrain development; Curcumin; GFAP; Nonylphenol; p-tau
dc.titleCurcumin Attenuates Nonylphenol-Induced Toxicity In Brain Development; An Experimental Study
dc.typeArticle

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