Comparison of efficacies of divalent, trivalent irons and divalent iron plus zinc preparations in paediatric patients with iron deficiency anemia

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dc.contributor.authorArabaci, Fatih Ibrahim
dc.contributor.authorKaya, Ali
dc.contributor.authorGültekin, Asim
dc.contributor.authorIça?asio?lu, Füsun Dilara
dc.contributor.authorMutlu, Esma Cansu
dc.date.accessioned2024-10-26T17:53:27Z
dc.date.available2024-10-26T17:53:27Z
dc.date.issued2010
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: In the present study, our aim was to determine the prevalence of iron deficiency (ID) and iron deficiency anaemia (IDA) in children between 6 months-6 years old and to compare efficacy of oral Fe+2 (ferrous sulphate), Fe+3 (ferric polymaltose) and Fe+2 + Zn (ferrous fumarate+zinc sulphate) preparations in the treatment of iron deficiency anaemia. Material and Methods: The present study was conducted on 271 children (aged 6 months to 6 years) applying to our polyclinic. ID was diagnosed if hemoglobine (Hb) concentration was >11 g/dL and ferritin level was <12 ng/mL. Eighty one of the cases included in the study and having Hb <11 g/dL and ferritin <12 ng/mL were diagnosed with IDA. Those having IDA were divided into three groups. Those in the first group (n= 27), second group (n= 28) and third group (n= 26) were randomized to Fe+2, Fe +3 and Fe+2 + Zntreatments respectively. Iron treatment was administered on empty stomach as 3 x 2 mg/kg/day for 12 weeks. Results: The prevalences of ID and IDA were found to be 19.6% and 29.9%. When the groups were compared in terms of post-treatment Hb values, the increase in Hb values of those in Fe+2 group was statistically significantly higher than those observed in other groups. When the increase in Hb values of Fe+3 and Fe+2 + Zn groups were compared, there was no statistically significant difference. When mean corpuscular volume, serum iron, ferritin and reticulocyte response were compared to each other, the difference between Fe+2 and Fe+3 groups was statistically significant whereas no statistically significant difference was found between Fe+2 and Fe+2 + Zn or between Fe+2 + Zn and Fe+3 groups. Conclusion: The prevalences of ID and IDA detected in our study are similar to those reported in previous studies. We believe that oral administration of Fe+2 preparations alone in IDA is more efficient. Copyright © 2010 by Türkiye Klinikleri.
dc.identifier.endpage215
dc.identifier.issn1300-0381
dc.identifier.issue3
dc.identifier.scopus2-s2.0-77956204818
dc.identifier.scopusqualityQ4
dc.identifier.startpage210
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26960
dc.identifier.volume19
dc.indekslendigikaynakScopus
dc.language.isotr
dc.relation.ispartofTurkiye Klinikleri Pediatri
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChild; Ferrous sulfate; Iron-deficiency anemia; Zinc sulfate
dc.titleComparison of efficacies of divalent, trivalent irons and divalent iron plus zinc preparations in paediatric patients with iron deficiency anemia
dc.title.alternativeÇocuklarda demir eksikli?i anemisinin tedavisinde +2 ve +3 de?erlikli demir i?çeren ve +2 de?erlikli demirle birlikte çinko i?çeren preperatlarin etkinliklerinin karşilaştirilmasi
dc.typeArticle

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