Chemokine receptor 5 ?32 gene polymorphism and abdominal aortic aneurysms

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dc.contributor.authorAydin, Murat
dc.contributor.authorKatrancio?lu, Nurkay
dc.contributor.authorManduz, Şinasi
dc.contributor.authorAtahan, Erhan
dc.contributor.authorKarahan, O?uz
dc.contributor.authorÖzdemir, Öztürk
dc.contributor.authorBerkan, Öcal
dc.date.accessioned2024-10-26T17:54:13Z
dc.date.available2024-10-26T17:54:13Z
dc.date.issued2010
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground: In this study, we aimed to investigate the relationship between abdominal aortic aneurysm (AAA) and chemokine receptor 5 ?32 (CCR5) gene polymorphism as a risk factor. Methods: Fifty-eight patients (41 males, 17 females; mean age 62.9±6.5 years; range 45 to 78 years) operated on our clinic between May 2008 and March 2009 with the diagnosis of AAA, and 58 healthy volunteers (38 males, 20 females; mean age 58.8±11.6 years; range 30 to 79 years) with normal aortic diameters measured by computed tomography were included in this study. Thirty-two base p deletions in the CCR5 gene were screened after obtaining genomic DNAs from peripheral blood samples of the patients. Results: When the groups were compared with the predisposing risk factors for the development of AAA, no significant difference was observed (p>0.05). Eleven patients (19.0%) had heterozygote CCR5 gene mutation in the AAA group, however, only one patient (1.7%) had heterozygote CCR5 gene mutation in the control group. While the CCR5 homozygote was normal in 47 (81.0%) patients, the CCR5 homozygote was normal in 57 (98.3%) volunteers in the control group. Chemokine receptor 5 ?32 heterozygote gene mutation was significantly higher in the AAA group. (p=0.004). Conclusion: Consequently, a relationship between CCR5 gene polymorphism and AAA was demonstrated in this study. We think that hereditary factors considered between unchanged etiologic factors play a role in the development of AAA and we believe that AAA can be treated before serious complications occur with frequent clinical check ups in people with hereditary predisposition.
dc.identifier.endpage289
dc.identifier.issn1301-5680
dc.identifier.issue4
dc.identifier.scopus2-s2.0-79957887388
dc.identifier.scopusqualityQ3
dc.identifier.startpage284
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27068
dc.identifier.volume18
dc.indekslendigikaynakScopus
dc.language.isotr
dc.relation.ispartofTurkish Journal of Thoracic and Cardiovascular Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject32 base p deletion; Abdominal aortic aneurysm; CCR5; Chemokine; Gene polymorphism
dc.titleChemokine receptor 5 ?32 gene polymorphism and abdominal aortic aneurysms
dc.title.alternativeKemokin reseptör 5 ?32 gen polimorfizmi ve abdominal aort anevrizmalari
dc.typeArticle

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