Association between Multiple Sclerosis and FOXP3 Gene promoter region mutations

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dc.contributor.authorÇekin, Nilgün
dc.contributor.authorPınarbaşı, Ergün
dc.contributor.authorBildirici, Aslihan Esra
dc.contributor.authorAkın, Şeyda
dc.contributor.authorYıldız, Özlem Kayım
dc.date.accessioned2024-10-26T17:44:18Z
dc.date.available2024-10-26T17:44:18Z
dc.date.issued2018
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractRegulatory T-Cells (Treg Cells), as one of the immune system components, have been highly effective in theautoimmune diseases prevention, particularly multiple sclerosis (MS). MS is a chronic inflammatory and autoimmunedisease characterized by immune infiltration and inflammation in the central nervous system. Regulatory T (Treg) cellsplay an important role in the control of autoimmunity. Expression and action of the transcription factor FOXP3 controlsthe development and function of Treg cell. The aim of this study was to investigate the association between MS andFOXP3 gene promoter region polymorphisms rs2232365 (-924A/G) and rs3761548 (-3279A/C) in a Turkishpopulation. In this case-control study we investigated these polymorphisms in 80 MS patients and 80 healthy controlsusing PCR-RFLP methods.Results of our study showed that while there is significant correlation between MS and FOXP3 rs3761548polymorphism (p=0.031), FOXP3 rs2232365 polymorphism, has not been found to be associated with the disease(p=0.31). As FOXP3 gene is one of the most important genes in the regulation of the immune cells, it may beconcluded that the expression of this gene is important in MS patients. As this SNP is located in the promoter region ofthe gene, it may affect the expression level of FOXP3 protein.
dc.identifier.doi10.7197/223.vi.419261
dc.identifier.endpage232
dc.identifier.issn1305-0028
dc.identifier.issue3
dc.identifier.startpage226
dc.identifier.trdizinid326207
dc.identifier.urihttps://doi.org/10.7197/223.vi.419261
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/326207
dc.identifier.urihttps://hdl.handle.net/20.500.12418/25194
dc.identifier.volume40
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofCumhuriyet Tıp Dergisi (ELEKTRONİK)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCerrahi
dc.titleAssociation between Multiple Sclerosis and FOXP3 Gene promoter region mutations
dc.typeArticle

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