Investigation of the Agents Isolated From the Blood Cultures of a University Hospital Neonatal Intensive Care Unit and Their Antimicrobial Susceptibility [2]

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dc.contributor.authorFırtına Topcu, Kübra
dc.contributor.authorHasbek, Mürşit
dc.contributor.authorÇabuk, Aslı
dc.date.accessioned2025-05-04T16:41:53Z
dc.date.available2025-05-04T16:41:53Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIntroduction: Neonatal sepsis is a clinical syndrome characterized by non-specific signs and symptoms caused by various pathogens. The diagnosis is based on a combination of clinical and laboratory findings. Gram-positive and Gram-negative bacteria are the predominant etiologic agents. In our study,we aimed to evaluate the types of microorganisms grown in neonatal blood cultures and antimicrobial susceptibilities of Gram-negative agents. Materials and Methods: We retrospectively analyzed 2566 blood culture results. Samples from blood culture bottles with growth were passaged on blood agar. The growing colonies were identified by MALDİ-TOF MS. Antibiotic susceptibility tests were performed on a fully automated device. The results were evaluated according to EUCAST standards. Results: Growth was detected in 12.1% of the samples. 59.5% of the patients with growth were male. 66% of the patients were at term and 53.7% had early-onset sepsis. 74.6% of the cases were cesarean section and 59.5% were above 2500 grams. Coagulase-negative staphylococci (CNS) were the most common organisms grown in early and late-onset sepsis. 73.9% CNS, 9% Gram-negative enteric and nonfermentary bacilli, 2.9% Gram-positive bacilli and 0.1% fungi were grown. 40% of S.aureus were methicillin resistant. The most antimicrobial-resistant Gram-negative agent was Klebsiella spp. Klebsiella spp. isolates were resistant to amikacin 9%, ampicillin 100%, cefepime 72.7%, ceftazidime 81.8%, gentamicin 81.8%, meropenem 9.1%. Extended spectrum beta lactamase was positive in 90.9%. Acinetobacter spp. isolates were resistant to amikacin 42.8%, ampicillin 42.8%, gentamicin 42.8%, meropenem 42.8%. Conclusion: Microorganism species and antibiotic susceptibilities in intensive care units vary over time and between clinics. Broad-spectrum antimicrobials started early with suspicion of sepsis without culture confirmation can be replaced with agent-specific narrow-spectrum antimicrobials when growth is detected in culture,monotherapy can be switched or treatment can be terminated early. This may contribute to the prevention of resistance development. © Telif Hakkı 2023 Bursa Uludağ Üniversitesi Çocuk Sağlığı ve Hastalıkları Anabilim Dalı / Güncel Pediatri, Galenos Yayınevi tarafından yayınlanmıştır.
dc.identifier.doi10.4274/jcp.2023.01069-2
dc.identifier.endpage181
dc.identifier.issn1304-9054
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85172874823
dc.identifier.scopusqualityQ4
dc.identifier.startpage171
dc.identifier.urihttps://doi.org/10.4274/jcp.2023.01069-2
dc.identifier.urihttps://hdl.handle.net/20.500.12418/34953
dc.identifier.volume21
dc.indekslendigikaynakScopus
dc.language.isotr
dc.publisherGalenos Publishing House
dc.relation.ispartofGuncel Pediatri
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250504
dc.subjectantimicrobial resistance
dc.subjectblood culture
dc.subjectKlebsiella
dc.subjectNewborn
dc.titleInvestigation of the Agents Isolated From the Blood Cultures of a University Hospital Neonatal Intensive Care Unit and Their Antimicrobial Susceptibility [2]
dc.title.alternativeBir Üniversite Hastanesi Yenidoğan Yoğun Bakım Ünitesi Kan Kültürlerinden İzole Edilen Etkenler ve Antimikrobiyal Duyarlılıklarının İncelenmesi [2]
dc.typeArticle

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