Composition characterization and biological activity study of Thymbra spicata l. var. spicata essential oil

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dc.contributor.authorEruygur, Nuraniye
dc.contributor.authorKocyıgıt, Umit M.
dc.contributor.authorAtas, Mehmet
dc.contributor.authorCevık, Ozge
dc.contributor.authorGökalp, Faik
dc.contributor.authorTaslimi, Parham
dc.contributor.authorGulcın, İlhami
dc.date.accessioned2024-10-26T17:46:03Z
dc.date.available2024-10-26T17:46:03Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThe current research aimed to determine and report in vitro antioxidant, antimicrobial, antibiofilm, cytotoxic, anti-cholinesterase, and anti-diabetic properties and the stability of the major component of basic oil of Thymbra spicata var. spicata through different phases as theoretically. Essential oil exhibits potential biological activities because of the multiple components it contains.In the current research, the evaluation of Thymbra spicata essential oil antioxidant properties was conducted utilizing 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2- azinobis[3-ethylbenzthiazoline]-6-sulfonic acid (ABTS) radical scavenging activity.Antimicrobial activity was assessed from minimum inhibition concentration (MIC) using the technique of microdilution and cytotoxicity activity was evaluated by MTT assay through MCF-7 and PC3 human cancer cell lines.Consequently, Cytotoxic activity was evaluated by means of MTT assay utilized. The essential oil was detected to have 340 ?g/mL inhibiting influence on the growth of PC3 prostate cancer cells with IC50 value. Also, the T. spicata plant was observed to significantly repress the enzymes, namely acetylcholinesterase (AChE), butyrylcholinesterase (BChE), ?-glycosidase. IC50 values of enzymes were obtained 0.23 ?g/mL for AChE, 1.64 ?g/mL for BChE, 7.78 ?g/mL for ?-glycosidase. It was concluded that this plant may be used for Alzheimer's and diabetes disease.
dc.identifier.endpage575
dc.identifier.issn2587-2680
dc.identifier.issn2587-246X
dc.identifier.issue3
dc.identifier.startpage565
dc.identifier.trdizinid1109255
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1109255
dc.identifier.urihttps://hdl.handle.net/20.500.12418/25812
dc.identifier.volume42
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofCumhuriyet Science Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleComposition characterization and biological activity study of Thymbra spicata l. var. spicata essential oil
dc.typeArticle

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