Therapeutic plasma exchange in patients with neurological diseases: Multicenter retrospective analysis

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dc.authoridAltuntas, Fevzi/0000-0001-6872-3780
dc.authoridYilmaz, Mehmet Birhan/0000-0002-8169-8628
dc.authoridKaya, Emin/0000-0001-8605-8497
dc.authoridERKURT, MEHMET ALI/0000-0002-3285-417X
dc.authoridKeklik, Muzaffer/0000-0002-6426-5249
dc.authoridCETIN, Mustafa/0000-0003-4512-1124
dc.contributor.authorKaya, Emin
dc.contributor.authorKeklik, Muzaffer
dc.contributor.authorSencan, Mehmet
dc.contributor.authorYilmaz, Mehmet
dc.contributor.authorKeskin, Ali
dc.contributor.authorKiki, Ilhami
dc.contributor.authorErkurt, Mehmet Ali
dc.date.accessioned2024-10-26T18:11:36Z
dc.date.available2024-10-26T18:11:36Z
dc.date.issued2013
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractTherapeutic plasma exchange (TPE), is a procedure, changing pathologic substances in the plasma of patients with replacement fluid. TPE has an increasing list of indications in recent years such as neurological, connective tissue, hematological, nephrological, endocrinological and metabolic disorders. We report our multicenter data about therapeutic plasma exchange in patients with neurological diseases. Six University Hospitals' aphaeresis units medical records about neurologic diseases were reviewed retrospectively. Hundred and fifteen patients and 771 TPE sessions from six aphaeresis units' were included to this study. Of the 115 patients, 53 (46%) were men and 62 (54%) were women. The median age was 50 (range: 5-85) years. Of these patients 58.3% were Guillain-Barre syndrome (GBS), 17.4% were acute disseminated encephalomyelitis (ADEM), 10.4% were chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), 7% were multiple sclerosis, 6.1% were myasthenia gravis (MG) and 0.9% were Wilson disease (WD). The median number of TPE sessions per patient was 5 (range 1-72). Human albumin was used as a replacement fluid in 66% and fresh frozen plasma was used in 34% of cases. TPE was done through central venous catheters in 66%, and peripheral venous access in 34% of patients. Some complications were seen in patients (18.3%) during TPE sessions. These complications were, complications related to catheter placement procedure (8.7%), hypotension (3.5%), hypocalcaemia (3.5%) and allergic reactions (1.7%). The complication ratios were 2.7% in total 771 TPE procedures. TPE procedure was terminated in 6% of sessions depending on these complications. Overall responses to TPE were noted in 89.5% of patients. In conclusion: Therapeutic plasma exchange is an effective treatment option in several neurologic diseases. (C) 2013 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.transci.2013.04.015
dc.identifier.endpage352
dc.identifier.issn1473-0502
dc.identifier.issue3
dc.identifier.pmid23619327
dc.identifier.startpage349
dc.identifier.urihttps://doi.org/10.1016/j.transci.2013.04.015
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30754
dc.identifier.volume48
dc.identifier.wosWOS:000321403400016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofTransfusion and Apheresis Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTherapeutic plasma exchange
dc.subjectGuillain-Barre syndrome
dc.subjectAcute disseminated encephalomyelitis
dc.subjectChronic inflammatory demyelinating polyradiculoneuropathy
dc.subjectMultiple sclerosis
dc.subjectMyasthenia gravis
dc.titleTherapeutic plasma exchange in patients with neurological diseases: Multicenter retrospective analysis
dc.typeArticle

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