Evaluation of Antibiofilm and Antimicrobial Activities of N-heterocyclic Carbene Complexes

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dc.contributor.authorTutar, Uğur
dc.contributor.authorÇelik, Cem
dc.contributor.authorAtaş, Mehmet
dc.date.accessioned2024-10-26T17:34:05Z
dc.date.available2024-10-26T17:34:05Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIn recent years, resistance to antimicrobials has become a global problem. Despite the need for new antibiotics with the increase of resistant bacteria, developing new antimicrobials is problematic. Biofilms formed by microorganisms play an essential role in the development of resistance. We aimed to investigate the antimicrobial and antibiofilm activities of N-heterocyclic carbene (NHC) complexes. In this study, previously synthesized and characterized NHC complexes on standard bacterial and fungal strains were investigated. The minimal inhibition concentration (MIC) test was used to determine the antimicrobial activities of the compounds, and the biofilm inhibition concentration test was used to determine the anti-biofilm activities. Compounds 2b and 2c showed potent antimicrobial activity on microorganisms between <=1.9 and 7.8µg/mL. Antimicrobial activity in salts of compounds (1a-1c) was weaker than silver compounds (2a-2c). The antibiofilm activity was between 27 and 79%, especially in silver-bound compounds (2a-2c). Benzimidazole derivative NHC compounds that we evaluated in our study were found to have significant antimicrobial and antibiofilm effects on pathogenic microorganisms. These compounds, which we assessed in our study, may be antimicrobial drug candidates that can be used in different areas. It will be essential to conduct further in vitro and in vivo studies on this subject.
dc.identifier.doi10.17776/csj.1390256
dc.identifier.endpage34
dc.identifier.issn2587-2680
dc.identifier.issn2587-246X
dc.identifier.issue1
dc.identifier.startpage29
dc.identifier.trdizinid1230137
dc.identifier.urihttps://doi.org/10.17776/csj.1390256
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1230137
dc.identifier.urihttps://hdl.handle.net/20.500.12418/23497
dc.identifier.volume45
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofCumhuriyet Science Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntimicrobial activity
dc.subjectAntibiofilm activity
dc.subjectBenzimidazole
dc.subjectN heterocyclic carbene
dc.titleEvaluation of Antibiofilm and Antimicrobial Activities of N-heterocyclic Carbene Complexes
dc.typeArticle

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