Investigation of potential DNA damaging and apoptotic effects of PLK1 inhibitor SBE13 in breast cancer cell line MDA-MB-231

Basit Öğe Kaydı
dc.contributor.authorErgül, Mustafa
dc.date.accessioned2024-10-26T17:34:08Z
dc.date.available2024-10-26T17:34:08Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractPolo-like kinase 1 (PLK1) regulates various steps of mitosis and aberrantly expressed in severaltumor types. As elevated levels of PLK1 contributes to tumorigenesis and poor prognosis,specific inhibition of PLK1 has garnered increasing attention in recent years in anticancerstudies. The objective of this study was to examine cytotoxic, apoptotic, and DNA-damagingpotentials of SBE13, a PLK1 inhibitor, against MDA-MB-231 breast cancer cells. Theregulatory efficacy of SBE13 on cell cycle arrest was also determined. Cytotoxicity of SBE13was assessed via XTT assay. Apoptosis, cell cycle distribution, and DNA damage responsewere also examined using the flow cytometry assay. The results revealed that SBE13 had adose-dependent cytotoxic effect in MDA-MB-231 cells. This compound has also induced cellcycle arrest at the G2/M point and significantly promoted apoptosis and DNA damage responsein MDA-MB-231 cells. Collectively, these data pointed out that SBE13 can be regarded as asuitable candidate for the therapy of breast cancer. However, further studies are required toconsolidate the anticancer activity of SBE13.
dc.identifier.doi10.17776/csj.774286
dc.identifier.endpage807
dc.identifier.issn2587-2680
dc.identifier.issn2587-246X
dc.identifier.issue4
dc.identifier.startpage802
dc.identifier.trdizinid456910
dc.identifier.urihttps://doi.org/10.17776/csj.774286
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/456910
dc.identifier.urihttps://hdl.handle.net/20.500.12418/23550
dc.identifier.volume41
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofCumhuriyet Science Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleInvestigation of potential DNA damaging and apoptotic effects of PLK1 inhibitor SBE13 in breast cancer cell line MDA-MB-231
dc.typeArticle

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu