Effect of adding dexmedetomidine to intra-articular levobupivacaine on postoperative pain following arthroscopic meniscus surgery: A prospective, double-blind, randomized, placebo-controlled, clinical trial

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dc.contributor.authorAvcı, Onur
dc.contributor.authorKol, İclal Özdemir
dc.contributor.authorGündoğdu, Oğuz
dc.contributor.authorÖztemur, Zekeriya
dc.contributor.authorErşan, İdris
dc.date.accessioned2024-10-26T17:53:05Z
dc.date.available2024-10-26T17:53:05Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: The aim of this study was to determine the effect of adding dexmedetomidine to intra-articular levobupivacaine on postoperative pain levels and analgesic requirements following arthroscopic meniscectomy. Methods: A total of 60 American Society of Anesthesiologist physical status I-II patients, aged 20 to 62 years, and scheduled for arthroscopic partial meniscectomy under general anesthesia were included in this study. All the patients were randomly assigned to one of four groups (15 patients in each group): Group 1 (8 male, 7 female; mean age = 46.70 ± 13.13 years; 0.9% isotonic 20 ml), group 2 (7 male, 8 female; mean age = 42.60 ± 12.18 years; levobupivacaine 0.5 mg/kg plus 0.9% isotonic), group 3 (8 male, 7 female; mean age = 43.80 ± 12.63 years; 1?g/kg dexmedetomidine plus 0.9% isotonic), and group 4 (7 female, 8 male; mean age = 40.40 ± 11.79 years; levobupivacaine 0.5 mg/kg plus 1?g/kg dexmedetomidine and 0.9% isotonic). All medications were administered at the end of arthroscopic surgery. Pain levels were measured using a Visual Analogous Scale (VAS) and Verbal Rating Scale (VRS) at postoperative 1, 2, 4, 6, 12, and 24 hours. Results: VAS scores at rest were significantly lower in Group 4 at postoperative 1th,2nd,4th,6th,12th, and 24th hours than in other groups. The time to take the first analgesic was significantly higher in Group4 (964 ± 288 min), and total analgesic consumption was significantly lower in Group 4 compared to those of other groups. Conclusion: Although administration of intra-articular dexmedetomidine alone may have a weaker effect than intra-articular levobupivacaine on postoperative pain relief after arthroscopic partial meniscectomy, adding dexmedetomidine to intra-articular levobupivacaine may increase the durationand quality of postoperative analgesia without any side effect. Level of Evidence: Level I, Therapeutic Study. © 2021, AVES. All rights reserved.
dc.identifier.doi10.5152/j.aott.2021.20212
dc.identifier.endpage320
dc.identifier.issn1017-995X
dc.identifier.issue4
dc.identifier.pmid34464306
dc.identifier.scopus2-s2.0-85114093321
dc.identifier.scopusqualityQ2
dc.identifier.startpage316
dc.identifier.urihttps://doi.org/10.5152/j.aott.2021.20212
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26706
dc.identifier.volume55
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAVES
dc.relation.ispartofActa Orthopaedica et Traumatologica Turcica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectArthroscopy; Dexmedetomidine; Intra-articular; Levobupivacaine
dc.titleEffect of adding dexmedetomidine to intra-articular levobupivacaine on postoperative pain following arthroscopic meniscus surgery: A prospective, double-blind, randomized, placebo-controlled, clinical trial
dc.typeArticle

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