Effectiveness of shear wave elastography for assessing major salivary gland involvement in ankylosing spondylitis

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dc.contributor.authorAtik, Irfan
dc.contributor.authorAtik, Seda
dc.contributor.authorGul, Enes
dc.date.accessioned2025-05-04T16:41:54Z
dc.date.available2025-05-04T16:41:54Z
dc.date.issued2025
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: To use shear wave elastography (SWE) in the evaluation of salivary glands in patients with ankylosing spondylitis (AS) who present with sicca symptoms. Materials and Methods: This was a prospective controlled study of patients diagnosed with AS and exhibiting sicca symptoms (study group) and of healthy volunteers (control group). The levels of antinuclear, anti-Ro, and anti-La antibodies were determined in blood samples. In both groups, parotid and submandibular glands were evaluated by ultrasound and tissue stiffness was determined by SWE. Intraclass correlation coefficients were used in order to assess reliability. The differences between the two groups were assessed by statistical methods, and a ROC curve analysis was performed to determine the predictive values. Results: A total of 66 patients with AS and 71 healthy volunteers were included in the study. There were no significant differences between the groups in terms of age or sex (p > 0.05). The intra-and inter-rater reliability of SWE were good for the parotid gland (0.81–0.85 and 0.80, respectively) and for the submandibular gland (0.85–0.88 and 0.80, respectively). Statistically significant differences were found. Tissue stiffness in the parotid and submandibular glands, as determined by SWE, was significantly greater in the study group than in the control group (p < 0.05). Conclusion: Although there was no histopathological correlation in the parotid and submandibular salivary glands of patients with AS and sicca symptoms compared with the healthy volunteers, quantitative measurements showed greater tissue stiffness in the former group. In patients with AS, SWE guides salivary gland biopsy, which is the gold standard for diagnosing Sjögren’s syndrome. © Colégio Brasileiro de Radiologia e Diagnóstico por Imagem.
dc.identifier.doi10.1590/0100-3984.2024.0121
dc.identifier.issn0100-3984
dc.identifier.scopus2-s2.0-105002126402
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1590/0100-3984.2024.0121
dc.identifier.urihttps://hdl.handle.net/20.500.12418/34965
dc.identifier.volume58
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherColegio Brasileiro de Radiologia
dc.relation.ispartofRadiologia Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250504
dc.subjectElasticity imaging techniques/methods
dc.subjectInflammation
dc.subjectSalivary glands/physiopathology
dc.subjectSpondylitis, ankylosing/diagnostic imaging
dc.subjectUltrasonography/methods
dc.titleEffectiveness of shear wave elastography for assessing major salivary gland involvement in ankylosing spondylitis
dc.title.alternativeEficácia da elastografia por ondas de cisalhamento para avaliar o envolvimento das glândulas salivares principais na espondilite anquilosante
dc.typeArticle

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