Elevated Levels of Activin-A, TNF-Alpha and IL-6 in Acromegaly

Basit Öğe Kaydı
dc.authoridbolat, serkan/0000-0002-8669-8782
dc.contributor.authorDogan, Kubra
dc.contributor.authorYildiz, Seyma Nur
dc.contributor.authorSariakcali, Baris
dc.contributor.authorDuman, Gulhan
dc.contributor.authorBolat, Serkan
dc.date.accessioned2024-10-26T18:07:13Z
dc.date.available2024-10-26T18:07:13Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractAlthough systemic inflammation has been linked to acromegaly, little is known about the abnormalities in cytokine networks during the disease. The aim of this study was to evaluate the serum concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and activin-A in acromegaly, and to investigate the relationship between TNF-alpha, IL-6, activin-A and comorbidities of acromegaly. A total of 56 subjects were recruited to the study. Serum samples were collected from 31 acromegaly patients and 25 healthy control subjects. Serum activin-A, IL-6 and TNF-alpha were determined using the enzyme-linked immunosorbent assay. Circulating levels of activin-A, TNF-alpha, and IL-6 were higher in patients than in the control group. Receiver operating characteristic analysis for activin-A for the differentiation of acromegaly patients from healthy control subjects showed an area under the curve of 0.90. Higher activin-A levels were determined in patients with residual pituitary tumor. These findings provide evidence for the role of activin-A, TNF-alpha and IL-6 in acromegaly. Serum activin-A levels could be used as a novel biomarker to diagnose acromegaly. These findings confirm previous studies that inflammation might be involved in the pathogenesis of acromegaly. Finally, treatment strategies targeting the regulation of inflammation cannot be sufficient alone in reducing comorbidities.
dc.identifier.doi10.1134/S181971242103003X
dc.identifier.endpage330
dc.identifier.issn1819-7124
dc.identifier.issn1819-7132
dc.identifier.issue3
dc.identifier.startpage325
dc.identifier.urihttps://doi.org/10.1134/S181971242103003X
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29371
dc.identifier.volume15
dc.identifier.wosWOS:000697656000014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherMaik Nauka/Interperiodica/Springer
dc.relation.ispartofNeurochemical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectacromegaly
dc.subjecttumor necrosis factor-alpha
dc.subjectinterleukin-6
dc.subjectactivin A
dc.subjectresidual pituitary tumor
dc.subjectserum
dc.subjectinflammation
dc.subjectcomorbidity
dc.titleElevated Levels of Activin-A, TNF-Alpha and IL-6 in Acromegaly
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu