Oxaliplatin and ototoxicity: Is it really safe for hearing?

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dc.contributor.authorYüce, Salim
dc.contributor.authorŞeker, Mehmet Metin
dc.contributor.authorKoç, Sema
dc.contributor.authorUysal, Ismail Önder
dc.contributor.authorKaçan, Turgut
dc.contributor.authorDo?an, Mehtap
dc.contributor.authorDo?an, Mansur
dc.date.accessioned2024-10-26T17:52:57Z
dc.date.available2024-10-26T17:52:57Z
dc.date.issued2014
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground/aim: Oxaliplatin is an effective and widely used chemotherapeutic agent in the treatment of many solid tumors. Te most common side effects are peripheral neuropathy, gastrointestinal toxicity, and neutropenia. There have been some case reports about ototoxicity with oxaliplatin, but no clinical trials. In this trial, we explored whether or not oxaliplatin has ototoxic effects. Materials and methods: A total of 18 patients, 14 with colorectal cancer and 4 with pancreatic cancer, were included in this study. Four patients (22%) were treated with a capecitabine and oxaliplatin (CapeOx) regimen, and 14 patients (78%) were treated with fluorouracil, leucovorin, and oxaliplatin (FOLFOX-6). Patients' pretreatment and posttreatment hearing levels were assessed with high-frequency audiometry and otoacoustic emission tests. Results: Te median time between the first and the last oxaliplatin doses was 3.2 months (range: 2-7 months). There was no hearing loss in tests conducted for both ears of patients at frequencies of 500, 1000, 2000, 4000, 6000, 8000, 12,000, and 16,000 Hz. There was no difference between the pretreatment and posttreatment otoacoustic emission tests. Conclusion: Oxaliplatin is a reliable agent in terms of ototoxicity. © TÜBİTAK.
dc.identifier.doi10.3906/sag-1304-76
dc.identifier.endpage589
dc.identifier.issn1300-0144
dc.identifier.issue4
dc.identifier.pmid25551926
dc.identifier.scopus2-s2.0-84901001870
dc.identifier.scopusqualityQ3
dc.identifier.startpage586
dc.identifier.urihttps://doi.org/10.3906/sag-1304-76
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26622
dc.identifier.volume44
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkiye Klinikleri Journal of Medical Sciences
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCancer; Ototoxicity; Oxaliplatin
dc.titleOxaliplatin and ototoxicity: Is it really safe for hearing?
dc.typeArticle

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