Association of plasma homocysteine level and carotid intima-media thickness in rheumatoid arthritis patients receiving methotrexate

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dc.contributor.authorHayta, Emrullah
dc.contributor.authorHizmetli, Sami
dc.contributor.authorAtalar, Mehmet Haydar
dc.contributor.authorÇinar, Ziynet
dc.date.accessioned2024-10-26T17:53:08Z
dc.date.available2024-10-26T17:53:08Z
dc.date.issued2015
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjectives: This study aims to evaluate the relationship between serum homocysteine levels and atherosclerotic plaques in carotid arteries in female patients with rheumatoid arthritis (RA). Patients and methods: Fifty-eight females with RA (mean age 45.50±11.69 years; range 42 to 60 years) and 22 female controls (mean age 47.3±8.9 years; range 38 to 62 years) with mechanical low back pain were included in the study. RA patients were divided into two groups: patients who were under methotrexate (MTX) therapy at least for two years (MTX group, n=32), and patients who did not receive MTX at least for past two years (non-MTX-disease-modifying antirheumatic drug group, n=26). RA patients’ disease activity scores in 28 joints were calculated. Carotid intima-media thickness and presence of atherosclerotic plaque were evaluated by high-resolution B-mode ultrasonography. Results: Plasma homocysteine levels were higher in MTX and non-MTX-disease-modifying antirheumatic drug groups compared to controls (16.88±6.84 and 10.37±2.54 ?mol/L, respectively) and the difference was statistically significant (p=0.001). In MTX, non-MTX-disease-modifying antirheumatic drug and control groups, atherosclerotic plaque was detected in 11 (34.5%) and four (15.4%) patients, and one patient (4.5%), respectively. Carotid intima-media thickness was significantly higher in MTX group compared to other two groups and the difference was statistically significant (p=0.002). Pearson correlation analysis revealed a significant correlation between intima-media thickness and homocysteine levels in MTX group (r=0.49, p=0.006). Conclusion: According to our study results, methotrexate treatment in female patients with RA increases plasma homocysteine levels and prevalence of atherosclerotic plaque. High homocysteine levels in these patients may be a cause of atherosclerosis. © 2015 Turkish League Against Rheumatism. All rights reserved.
dc.identifier.doi10.5606/ArchRheumatol.2015.4249
dc.identifier.endpage220
dc.identifier.issn2148-5046
dc.identifier.issue3
dc.identifier.scopus2-s2.0-84941080126
dc.identifier.scopusqualityQ4
dc.identifier.startpage214
dc.identifier.urihttps://doi.org/10.5606/ArchRheumatol.2015.4249
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26746
dc.identifier.volume30
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTurkish League Against Rheumatism (TLAR)
dc.relation.ispartofArchives of Rheumatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAtherosclerosis; B-mode ultrasonography; Homocysteine; Rheumatoid arthritis
dc.titleAssociation of plasma homocysteine level and carotid intima-media thickness in rheumatoid arthritis patients receiving methotrexate
dc.typeArticle

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