Metabolomics in traumatic brain injuries

Traumatic brain injury (TBI) is an important pathology that can cause severe disability and unexpected sudden death. In the pathogenesis of TBI, many biochemical reactions develop at the cellular level and these mechanisms can cause significant changes in some of the body's metabolites. Clinical, radiological, and biochemical data are used in the evaluation of traumatic brain injuries due to the complex physiology of the brain. For the classification of trauma, clinicians often use the Glasgow Coma Scale (GCS). In addition, radiologically taken MR Spectroscopy evaluations and biochemical markers made from samples such as blood and cerebrospinal fluid provide enlightening information about TBI. Metabolomics can be biochemically detected in body fluids such as blood, cerebrospinal fluid, etc., in sudden traumatic brain injury and can give important information about the course of the disease and the severity of the trauma and the mortality and morbidity of the patient. © 2023 Nova Science Publishers, Inc. All rights reserved.