Effect of dexpanthenol on cyclophosphamide-induced ovarian toxicity: a histological and molecular study in rats

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dc.authoridhttps://orcid.org/0000-0002-2163-6214
dc.authoridhttps://orcid.org/0000-0003-1297-426X
dc.authoridhttps://orcid.org/0000-0003-1941-1830
dc.authoridhttps://orcid.org/0000-0002-4457-1249
dc.contributor.authorEkici, Mehmet
dc.contributor.authorAteş, Mehmet Burak
dc.contributor.authorBaş-Ekici, Hacer
dc.contributor.authorÖzgür, Aykut
dc.date.accessioned2025-05-06T12:53:09Z
dc.date.available2025-05-06T12:53:09Z
dc.date.issued2024/05
dc.departmentFakülteler, Veteriner Fakültesi, Temel Bilimler Bölümü
dc.description.abstractAbstract Research question: Does dexpanthenol work as an effective therapeutic agent against cyclophosphamide (CYC)-induced premature ovarian failure (POF) in rats? Design: A total of 28 female Wistar Albino rats were randomly divided into four groups (n = 7 per group). The POF and POF plus dexpanthenol groups were intraperitoneally administered CYC at an initial dose of 50 mg/kg, followed by 8 mg/kg for 14 days. The dexpanthenol and POF plus dexpanthenol groups were both intraperitoneally administered dexpanthenol at a dose of 500 mg/kg/day for 15 days. Results: In the group administered CYC, the following was observed: a decrease in the ovarian index; a decrease in the numbers of primordial, primary, secondary and antral follicles; an increase in the number of corpus luteum and atretic follicles; a decrease in proliferation cell nuclear antigen immunoreactivity; a significant reduction in anti-Müllerian hormone and oestradiol levels; and an increase in serum FSH levels compared with controls. Dexpanthenol, on the other hand, reversed these effects. Quantitative reverse transcription polymerase chain reaction analyses showed that dexpanthenol increased Bcl-2, Akt1, mTOR, Nrf2 and HO-1 in CYC-induced ovarian tissues, but decreased Bax, Cas3, Hsp27, Hsp70, and Hsp90. Dexpanthenol treatment has a potential for inhibiting the intrinsic apoptotic pathway and oxidative stress levels in ovarian tissues via the downregulation of the mRNA expression of heat shock proteins and the activation of Nrf2/HO-1 pathways. Conclusions: Our findings demonstrated that dexpanthenol is an effective agent against POF caused by CYC; however, further experimental and clinical data are needed to use it effectively. Keywords: Apoptosis; Cyclophosphamide; Dexpanthenol; POF; Reproductive toxicology.
dc.identifier.citationEkici, M., Ateş, M. B., Baş-Ekici, H., & Özgür, A. (2024). Effect of dexpanthenol on cyclophosphamide-induced ovarian toxicity: a histological and molecular study in rats. Reproductive biomedicine online, 48(5), 103778. https://doi.org/10.1016/j.rbmo.2023.103778
dc.identifier.doi10.1016/j.rbmo.2023.103778
dc.identifier.endpage103778
dc.identifier.issn1472-648
dc.identifier.issue5
dc.identifier.startpage103778
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35708
dc.identifier.volume48
dc.identifier.wos001289860000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.institutionauthorEkici , Mehmet
dc.institutionauthoridhttps://orcid.org/0000-0002-2163-6214
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofReproductive Biomedicine Online
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleEffect of dexpanthenol on cyclophosphamide-induced ovarian toxicity: a histological and molecular study in rats
dc.typeArticle

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