Analysis of Ki-ras exon 2 gene mutations in 3-methylcholanthrene and butylated hydroxytoluene-induced rat lung tissues

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dc.contributor.authorPolat, Fikriye
dc.contributor.authorÖzdemir, Öztürk
dc.contributor.authorElagöz, Şahende
dc.date.accessioned2024-10-26T17:53:25Z
dc.date.available2024-10-26T17:53:25Z
dc.date.issued2008
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstract3-Methylcholanthrene (MCA) is a polycyclic aromatic hydrocarbon and potent carcinogenic agent that is often used in experimental cancer studies. Butylated hydroxytoluene (BHT) has been widely used for many years as an antioxidant to preserve and stabilize the freshness, nutritional value, flavor, and color of foods. The aim of the present study was to investigate the role of the application of MCA and BHT in the development of lung cancer, and to detect any mutation in the Ki-ras gene exon 2. Rats were killed by cervical dislocation 26 weeks after the last BHT injection and lung tissues were surgically removed. Lung tissues of the control and experiment rat groups were examined for point mutations in the exon 2 of the Ki-ras by PCR based SSCP analysis. No point mutation was observed in the Ki-ras gene exon 2. © TÜBİTAK.
dc.identifier.endpage282
dc.identifier.issn1300-0152
dc.identifier.issue4
dc.identifier.scopus2-s2.0-56049111055
dc.identifier.scopusqualityQ2
dc.identifier.startpage277
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26935
dc.identifier.volume32
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofTurkish Journal of Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject3-methylcholanthrene; Butylated hydroxytoluene; Ki-ras gene; Mutation; Rat lung tissue
dc.titleAnalysis of Ki-ras exon 2 gene mutations in 3-methylcholanthrene and butylated hydroxytoluene-induced rat lung tissues
dc.typeArticle

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