Investigation of gene expression levels in thyroid tissues of rats treated with Wi-Fi electromagnetic wave (2.4-3 GHz Wi-Fi RF-EMF)

Basit Öğe Kaydı
dc.contributor.authorSerin, Musa
dc.contributor.authorSoylu, Sinan
dc.contributor.authorDastan, Sevgi Durna
dc.contributor.authorKoc, Suleyman
dc.contributor.authorKurt, Atilla
dc.date.accessioned2024-10-26T18:03:53Z
dc.date.available2024-10-26T18:03:53Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIn this study, it was aimed to examine the effects of wireless waves applied to rats in the thyroid tissue by evaluating gene expression levels on 12 determined gene regions. 20 healthy 16-week-old Wistar albino female rats weighting 200-220 g were used. In the experiments, two groups, control and experimental groups, were formed, and ten female rats were used in each group. While WI-FI electromagnetic field was applied to the experimental group of these rats, nothing was applied to the control group. Many different gene regions, including beta catenin, beta-actin, GAPDH, L3B, HIF 1-Alpha, GSk-3B, TCF, WNT7a, WNT10a, WNT2, Beclin 1 and Beclin 2, ATG5 and ATG12, were investigated. ACTB and GAPDH gene primers were used as a house keeping gene. The fold change values were calculated statistically from the data obtained from the gene expression re-sults. Compared to the control group, it was observed that the experimental group had significant increases in gene expression levels of many gene regions investigated in the study (P<0.05). Among the study groups, 12 different genes such as beta catenin, beta-actin, GAPDH, L3B, HIF 1-Alpha, GSk-3B, TCF, WNT7a, WNT10a, WNT2, Beclin 1 and Beclin 2, ATG5 and ATG12, which we have determined according to the literature, are known to be related to autophagy and oxidative stress. When the expression levels were investigated, it was determined that the expression coefficients of all the genes studied in the wnt/ss catenin pathway in the experimental group of rats exposed to the Wi-Fi EM field, except for ATG5 and ATG12, were quite high, and there was significant differences between the groups.
dc.identifier.doi10.1016/j.molstruc.2023.135741
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2023.135741
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28634
dc.identifier.volume1288
dc.identifier.wosWOS:001013006800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectElectromagnetic wave
dc.subjectGene expression
dc.subjectqRT-PCR
dc.subjectWi-Fi RF-EMF exposure
dc.subjectThyroid
dc.titleInvestigation of gene expression levels in thyroid tissues of rats treated with Wi-Fi electromagnetic wave (2.4-3 GHz Wi-Fi RF-EMF)
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu