Glutathione S-transferase polymorphisms and their role in recurrent pregnancy loss: A genetic risk assessment

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dc.contributor.authorAkkus, Nejmiye
dc.contributor.authorKurtulgan, Hande Kucuk
dc.date.accessioned2025-05-04T16:45:37Z
dc.date.available2025-05-04T16:45:37Z
dc.date.issued2025
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: The frequency of recurrent pregnancy loss in society is 3-5%. Experts suggest that genetics account for over 80% of unexplained recurrent pregnancy loss. Glutathione S-transferase (GST) enzymes, regulated by GST genes, facilitate the detoxification of a variety of naturally occurring metabolites as well as environmentally derived chemicals. This research aimed to investigate GST gene polymorphisms as a potential risk factor in recurrent pregnancy loss etiology in the Turkish population. Materials and Methods: This study involved 107 recurrent pregnancy loss patients who sought treatment at the Sivas Cumhuriyet University Faculty of Medicine, Department of Medical Genetics, along with a control group of 107 individuals who had a successful birth and no previous history of miscarriage. The multiplex polymerase chain reaction and restriction fragment length polymorphism techniques were employed to analyze GSTM1, GSTT1 and GSTP1 gene polymorphisms in these cases. Results: GSTT1 null genotype (X2=4.74; p=0.029) and GSTT1/GSM1 null genotype (X2=3.333; p=0.047) were associated with statistically significant differences between the study groups. No statistical significance was detected when considering the GSTM1 null genotype (X2=3.326; p=0.068) or the GSTM1/GSTP1 and GSTT1/GSTP1 gene polymorphisms. Conclusion: A statistically significant association was observed between the GSTT1 null genotype and the diseased group. Our research demonstrated a substantial increase in the risk of recurrent pregnancy loss in the Turkish population, specifically among individuals with the GSTM1-null genotype. No statistical correlation was found between the GSTM1 and GSTP1 gene polymorphisms and recurrent pregnancy loss. Furthermore, no statistical significance was observed when they were assessed together.
dc.description.sponsorshipSivas Cumhuriyet University Scientific Research Projects Unit
dc.description.sponsorshipThis study was supported by Sivas Cumhuriyet University Scientific Research Projects Unit.
dc.identifier.doi10.4274/tjod.galenos.2025.57609
dc.identifier.endpage25
dc.identifier.issn2149-9322
dc.identifier.issn2149-9330
dc.identifier.issue1
dc.identifier.pmid40062625
dc.identifier.scopusqualityQ3
dc.identifier.startpage19
dc.identifier.urihttps://doi.org/10.4274/tjod.galenos.2025.57609
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35148
dc.identifier.volume22
dc.identifier.wosWOS:001448281000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofTurkish Journal of Obstetrics and Gynecology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250504
dc.subjectGlutathione S-transferase
dc.subjectGSTM1
dc.subjectGSTT1
dc.subjectGSTP1
dc.subjectrecurrent pregnancy loss
dc.titleGlutathione S-transferase polymorphisms and their role in recurrent pregnancy loss: A genetic risk assessment
dc.typeArticle

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