Design, fabrication, and characterization of o-phenylenediamine surface-conjugated carbon quantum nanodots as a potential new bioactive formulation

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dc.contributor.authorKarakus, Gulderen
dc.date.accessioned2024-10-26T17:51:35Z
dc.date.available2024-10-26T17:51:35Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThe aim of this study was to design and characterize a candidate molecule of biological significance by synergistically combining the unique chemical properties, biocompatibility, and low toxicity of carbon quantum dots (CNDs) by the precursor molecule o-phenylenediamine (o-PDA), which is used to produce most chemotherapeutic agents, as a CNDs/o-PDA conjugate. Using citric acid (CA), surface-functional CNDs were synthesized by simple and rapid thermal pyrolysis for 2 h at 180 °C without using chemicals. Conjugation was carried out for 16 h at 40 °C in N,N-dimethylformamide (DMF) presence of triethylamine (Et3N). Structural characterizations were performed by spectroscopic techniques such as attenuated total reflectance—Fourier transform infrared (ATR-FTIR), nuclear magnetic resonance (1H-NMR), UV–Vis, and fluorescence spectroscopy. The crystal structure of pure- and o-PDA-conjugated-CNDs was characterized using X-ray diffractometers (XRD-MF). Physical characterizations were performed by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). Q-TOF LC/MS (liquid chromatography–quadrupole-time-of-flight mass spectrometry) and size exclusion chromatography (SEC) were used to analyze molecular weight change and polydispersity index (PDI) as a result of o-PDA conjugation. The spherical nanoparticle size of the nanodots was confirmed by transmission electron microscopy (TEM). All results suggest that the targeted o-PDA derivatization of CNDs was successfully achieved by the ring-opening reaction. © 2023, King Abdulaziz City for Science and Technology.
dc.identifier.doi10.1007/s13204-023-02962-8
dc.identifier.endpage6696
dc.identifier.issn2190-5509
dc.identifier.issue9
dc.identifier.scopus2-s2.0-85172892257
dc.identifier.scopusqualityQ2
dc.identifier.startpage6667
dc.identifier.urihttps://doi.org/10.1007/s13204-023-02962-8
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26298
dc.identifier.volume13
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.relation.ispartofApplied Nanoscience (Switzerland)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCarbon quantum nanodots; o-Phenylenediamine; Structural characterization; Surface modification
dc.titleDesign, fabrication, and characterization of o-phenylenediamine surface-conjugated carbon quantum nanodots as a potential new bioactive formulation
dc.typeArticle

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