Highly Up-Regulation of Fas Ligand Gene Expression after Increasing in Oxidized Low-Density Lipoprotein

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dc.contributor.authorBayyurt, Burcu
dc.contributor.authorArslan, Serdal
dc.date.accessioned2025-05-04T16:39:45Z
dc.date.available2025-05-04T16:39:45Z
dc.date.issued2025
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractOxidized low-density lipoprotein (ox-LDL) shows many harmful effects such as induction of apoptosis on function of endothelial cell (EC). Fas ligand (FASL) induces apoptosis in divergent pathological conditions. EC apoptosis which induced by ox-LDL is related with FASL. In this study, we aimed to determine how different ox-LDL levels affect FASL expression in ECs. We treated human umbilical vein endothelial cells (HUVECs) with two different concentration of ox-LDL. FASL gene expression in groups was detected by quantitative polymerase chain reaction (qPCR). We compared FASL gene expression level between the groups according to ∆∆Ct method. FASL gene expression was statistic significantly up-regulated in the group treated higher amounts of ox-LDL (P<0.001). We found that treatment with higher amounts of ox-LDL in HUVECs increased FASL gene expression dramatically. According to our findings, we concluded that increasing the amount of ox-LDL may be critical in inducing the FASL-dependent apoptotic pathway in ECs.
dc.identifier.doi10.34248/bsengineering.1578992
dc.identifier.endpage57
dc.identifier.issn2619-8991
dc.identifier.issue1
dc.identifier.startpage54
dc.identifier.trdizinid1295867
dc.identifier.urihttps://doi.org/10.34248/bsengineering.1578992
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1295867
dc.identifier.urihttps://hdl.handle.net/20.500.12418/34848
dc.identifier.volume8
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofBlack Sea Journal of Engineering and Science
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR_20250504
dc.subjectFas ligand
dc.subjectGene expression
dc.subjectHuman umbilical vein endothelial cell
dc.subjectOxidized low-density lipoprotein
dc.subjectQuantitative polymerase chain reaction
dc.titleHighly Up-Regulation of Fas Ligand Gene Expression after Increasing in Oxidized Low-Density Lipoprotein
dc.typeArticle

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