The possible effects of COVID-19 on the human reproductive system

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dc.contributor.authorDağdeviren, Tuğba
dc.contributor.authorYolcu, Hatice Kübra
dc.date.accessioned2024-10-26T17:37:53Z
dc.date.available2024-10-26T17:37:53Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractSpike surface glycoprotein and small envelope matrix-nucleocapsid proteins, is from the Coronaviridae family and binds to host receptors via spike surface proteins. Although it shows its symptoms especially on the respiratory tract, various studies have been carried out considering that it also affects other systems in the body. For the virus to enter the host cell, it must bind to ACE2 (angiotensin converting enzyme 2). ACE2 is a key protein involved in balancing Ang I and Ang II levels. With receptors such as TMPRSS2 (transmembrane serine protease 2), the effects of the virus on the human reproductive system are much better understood. Since human germ cells and early embryos express ACE2, there is a potential risk of the Coronavirus associated with germ cells. Studies show that the coronavirus changes the amount and density of hormones in the human reproductive system. The fact that most of the partners of 35 female patients who had SARS-CoV-2 in the studies were infected individuals suggests that sexual transmission may be possible. It was determined that TMPRSS4, Cathepsin B and L, FURIN, MX1 and BSG gene expressions were high in the menstrual cycle, while ACE 2 and TMPRSS2 were moderately expressed. It has been shown that the ACE2 enzyme is most intensely expressed is the testes. Studies have shown that sperm DNA (deoxyribonucleic acid) fragmentation, changes in hormone levels and the formation of anti-sperm antibodies are an important cause of male infertility. Infected men have been found to have an impaired spermatogenesis. This rewiew; it aims to draw attention to the possible effects of the corona virus on the human reproductive system and to reveal new mechanisms for new research to be done.
dc.identifier.doi10.18621/eurj.1193573
dc.identifier.endpage1508
dc.identifier.issn2149-3189
dc.identifier.issue6
dc.identifier.startpage1502
dc.identifier.trdizinid1207263
dc.identifier.urihttps://doi.org/10.18621/eurj.1193573
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1207263
dc.identifier.urihttps://hdl.handle.net/20.500.12418/23687
dc.identifier.volume9
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofThe European Research Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCOVID-19
dc.subjectTMPRSS2
dc.subjectACE2
dc.subjecthuman reproductive system
dc.titleThe possible effects of COVID-19 on the human reproductive system
dc.typeReview Article

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