Surgical Antimicrobial Prophylaxis Compliance in Turkey: Data from the Prospective, Observational, Multicenter Survey Including 7,978 Surgical Patients

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dc.contributor.authorEkinci, Semiha Celik
dc.contributor.authorYenilmez, Ercan
dc.contributor.authorOcal, Gulfem Akengin
dc.contributor.authorSonmezer, Meliha Cagla
dc.contributor.authorTarakci, Arzu
dc.contributor.authorAygun, Cemanur
dc.contributor.authorAkdag, Damla
dc.date.accessioned2024-10-26T18:11:48Z
dc.date.available2024-10-26T18:11:48Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground: Surgical antimicrobial prophylaxis (SAP) is the peri-operative administration of antimicrobial agents. Compliance rates vary worldwide from 15% to 84.3%, with studies in Turkey not exceeding 35%. The aim of this multicenter study was to determine the rate of appropriate antibiotic class, timing, and duration as well as discharge prescriptions in Turkey. Thus, we aimed to determine the rate of full compliance with SAP procedures in our country Patients and Methods: This multicenter, prospective, observational, descriptive study was conducted in 47 hospitals from 28 provinces in seven different regions of Turkey. Patients over 18 years of age in all surgical units between June 6, 2022, and June 10, 2022, were included in the study. Results: Of the 7,978 patients included in the study, 332 were excluded from further analyses because of pre-existing infection, and SAP compliance analyses were performed on the remaining 7,646 cases. The antibiotic most commonly used for SAP was cefazolin (n = 4,701; 61.5%), followed by third-generation cephalosporins (n = 596; 7.8%). The most common time to start SAP was within 30 minutes before surgery (n = 2,252; 32.5%), followed by 30 to 60 minutes before surgery (n = 1,638; 23.6%). Surgical antimicrobial prophylaxis duration was <24 hours in 3,516 (50.7%) patients and prolonged until discharge in 1,505 (21.7%) patients. Finally, the actual proportion of patients compliant with SAP was 19% (n = 1,452) after omitting 4,458 (58.3%) patients who were prescribed oral antibiotic agents at discharge as part of a prolonged SAP. Conclusions: Surgical antimicrobial prophylaxis compliance rates are still very low in Turkey. Prolonged duration of SAP and especially high rate of antibiotic prescription at discharge are the main reasons for non-compliance with SAP.
dc.description.sponsorshipAssociation for the Prevention of Infectious Diseases (BUHASDER)
dc.description.sponsorshipThe Surgical Prophylaxis Working Group of the Association for the Prevention of Infectious Diseases (BUHASDER) conducted this study
dc.identifier.doi10.1089/sur.2023.243
dc.identifier.endpage239
dc.identifier.issn1096-2964
dc.identifier.issn1557-8674
dc.identifier.issue3
dc.identifier.startpage231
dc.identifier.urihttps://doi.org/10.1089/sur.2023.243
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30830
dc.identifier.volume25
dc.identifier.wosWOS:001198379800015
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofSurgical Infections
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectantibiotic resistance
dc.subjectantimicrobial stewardship
dc.subjectcompliance rate of SAP
dc.subjectperi-operative care
dc.subjectsurgical antimicrobial prophylaxis
dc.titleSurgical Antimicrobial Prophylaxis Compliance in Turkey: Data from the Prospective, Observational, Multicenter Survey Including 7,978 Surgical Patients
dc.typeArticle

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