Does hepatic visualisation show residual/metastatic thyroid tissue in differentiated thyroid cancer?

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dc.authoridCIFTCI, ESRA -- 0000-0001-6106-7733en_US
dc.contributor.authorHasbek, Zekiye
dc.contributor.authorGul, Serdar Savas
dc.contributor.authorCiftci, Esra
dc.contributor.authorErturk, Seyit Ahmet
dc.contributor.authorCakmakcilar, Ali
dc.contributor.authorDuman, Gulhan
dc.contributor.authorTurgut, Bulent
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:37:26Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:37:26Z
dc.date.issued2019
dc.department[Hasbek, Zekiye -- Erturk, Seyit Ahmet -- Cakmakcilar, Ali] Cumhuriyet Univ, Sch Med, Dept Nucl Med, TR-58140 Sivas, Turkey -- [Gul, Serdar Savas] Gaziosmanpasa Univ, Sch Med, Dept Nucl Med, Tokat, Turkey -- [Ciftci, Esra] Sakarya Univ, Sch Med, Dept Nucl Med, Sakarya, Turkey -- [Duman, Gulhan] Cumhuriyet Univ, Sch Med, Dept Endocrinol, Sivas, Turkey -- [Turgut, Bulent] Katip Celebi Univ, Sch Med, Dept Nucl Med, Izmir, Turkeyen_US
dc.description.abstractAim: Diffuse homogen hepatic uptake in whole-body scan (WBS) after radioiodine remnant ablation (RRA) suggests that there is occult or visible remnant thyroid tissue and/or tumor tissue. It is thought that the reason is hepatic metabolization of radioiodine (1311) marked thyroglobulin fragments which are secreted by remnant/tumor tissue. The aims of this study were to investigate whether the hepatic visualisation after radioiodine remnant ablation showed the presence of metastatic or residual disease in patients with differentiated thyroid cancer and also to investigate whether early or late WBS after RRA (RxWBS) had an effect on the physiological hepatic uptake. Material and Method: 201 DTC patients were evaluated (F/M: 152/49; mean age: 49.61 +/- 13 years (range: 18-85 years)) who referred for RRA. The therapeutic 1311 dose ranged from 100mCi to 200mCi. RxWBS was performed earlier (in 1-4th-day after RRA) in 106 patients (Group 1) and was performed later (in 5-9th-day after RRA) in 95 patients (Group 2). Results: Diffuse hepatic uptake were seen only in three patients (2.8%) and was not seen in 103 patients (97.2%) in Group 1. However, in Group 2 diffuse hepatic uptake was seen in 93 patients (97.9%) (p<0.05) and not seen only in 2 patients (2.1%). There is not a statistically significant relationship between the hepatic uptake and serum Tg. LT4 and TSH level. There is a statistically significant relationship between anti-Tg level and hepatic uptake. Discussion: Physiological diffuse hepatic uptake of radioiodine in WBS after RRA may not be seen during the early WBS. Thus, metastatic foci may be missed with early scanning. We conclude that RxWBS after RRA should be done in late period.en_US
dc.identifier.doi10.4328/JCAM.5838en_US
dc.identifier.endpage53en_US
dc.identifier.issn1309-0720
dc.identifier.issn1309-2014
dc.identifier.issue1en_US
dc.identifier.startpage49en_US
dc.identifier.urihttps://dx.doi.org/10.4328/JCAM.5838
dc.identifier.urihttps://hdl.handle.net/20.500.12418/6068
dc.identifier.volume10en_US
dc.identifier.wosWOS:000451875800011en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherDERMAN MEDICAL PUBLen_US
dc.relation.ispartofJOURNAL OF CLINICAL AND ANALYTICAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDifferentiated Thyroid Canceren_US
dc.subjectRadioiodineen_US
dc.subjectHepatic Uptakeen_US
dc.subjectScintigraphyen_US
dc.titleDoes hepatic visualisation show residual/metastatic thyroid tissue in differentiated thyroid cancer?en_US
dc.typeArticleen_US

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