Differentiation of rheumatoid arthritis from HCV infection: Rheumatoid factor, anti-cyclic citrullinated peptide or anti-mutated citrullinated vimentin?

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dc.contributor.authorKaptano?lu, Ece
dc.contributor.authorNadir, Işilay
dc.contributor.authorBakici, Zahir
dc.contributor.authorHayta, Emrullah
dc.contributor.authorTürkmen, Mehmet
dc.contributor.authorSezer, Hafize
dc.contributor.authorHizmetli, Sami
dc.date.accessioned2024-10-26T17:54:25Z
dc.date.available2024-10-26T17:54:25Z
dc.date.issued2010
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: Differentiation of rheumatoid arthritis (RA) from other diseases with joint involvement such as hepatitis-C virus (HCV) infection represents a diagnostic problem. In addition to the rheumatoid factor (RF), more specific and sensitive auto-antibodies are under evaluation in recent years with conflicting results. In this study, we tested the diagnostic value of rheumatoid factor, anti-cyclic citrullinated peptide (anti-CCP) and anti-mutated citrullinated vimentin (anti-MCV) in distinguishing RA from hepatitis C patients. Materials and Methods: Sera of 34 RA patients and 30 hepatitis C patients were tested for RF, anti-CCP anti-MCV. Disease activity was determined by disease activity score (DAS-28) 28 in RA and by modified Knodell score in hepatitis C patients. Extra-articular involvement in RA and rheumatologic involvement in hepatitis C patients were documented. Results: In roc analysis, area under curve (AUC) was the highest in anti-CCP. Sensitivity and specificity was 82% and 53%, 79%, and 96% and 70%, and 73% for RF, anti-CCP and anti-MCV respectively. DAS-28 has a weak correlation with RF (r=0.406), anti-CCP (r=0.433), and anti-MCV (r=0.453). There was no difference between the patients in autoantibody levels regarding extra-articular involvement and DAS-28 in RA, and joint involvement in hepatitis C patients. Conclusion: Anti-MCV antibodies may be useful in distinguishing RA however it seems to have no additional value over anti-CCP or RF in hepatitis C patients. Anti-CCP antibodies are more reliable in diagnosis of RA due to their high specificity.
dc.identifier.endpage23
dc.identifier.issn1309-0291
dc.identifier.issue1
dc.identifier.scopus2-s2.0-77951640959
dc.identifier.scopusqualityN/A
dc.identifier.startpage19
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27179
dc.identifier.volume25
dc.indekslendigikaynakScopus
dc.language.isotr
dc.publisherAves Yayincilik
dc.relation.ispartofTurkish Journal of Rheumatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnti-CCP; Anti-MCV; HCV; Rheumatoid arthritis; Rheumatoid factor
dc.titleDifferentiation of rheumatoid arthritis from HCV infection: Rheumatoid factor, anti-cyclic citrullinated peptide or anti-mutated citrullinated vimentin?
dc.title.alternativeRomatoid artritin HCV enfeksiyonundan ayrılmasında romatoid faktör, anti-siklik sitrüline peptid ve anti-mutated sitrüline vimentinin yeri
dc.typeArticle

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