Effectiveness of Different P2Y12 Inhibitors on Coronary Flow in Patients with ST-Elevation Myocardial Infarction

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dc.authoridYenercag, Mustafa/0000-0002-0933-7852
dc.contributor.authorSeker, Onur Osman
dc.contributor.authorCerik, Idris Bugra
dc.contributor.authorCoksevim, Metin
dc.contributor.authorYenercag, Mustafa
dc.contributor.authorSoylu, Korhan
dc.date.accessioned2024-10-26T18:09:43Z
dc.date.available2024-10-26T18:09:43Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground: ST-segment elevation myocardial infarction (STEMI) is a clinical syndrome with high mortality. The main purpose of STEMI treatment is to achieve optimal revascularization for tissue perfusion. Besides the innovations in revascularization strategies, developments in antithrombotic therapy resulted in a significant reduction in STEMI-related mortality. Reperfusion can be demonstrated by resolution of ST-segment elevation (STR), TIMI frame count (TFC), and myocardial blush grade (MBG). Aim of the study: In our study, we investigated the effects of P2Y12 inhibitors clopidogrel, prasugrel, and ticagrelor on reperfusion parameters such as TFC, MBG, and STR, after primary percutaneous coronary intervention (pPCI) in STEMI. Material and Methods: The study was a retrospective analysis of STEMI patients who underwent successful pPCI. A total of 120 patients were included in the study as 3 equal groups according to the type of P2Y12 inhibitor administered in loading dose in the acute phase, and reperfusion parameters were compared between the groups. Results: There was no statistically significant difference between the groups in terms of baseline demographic, clinical, and angiographic parameters. Evaluation of reperfusion parameters indicated that STR, MBG, angina relief after pPCI and corrected TFC (cTFC) were significantly different between the groups (p<0.05). In post-hoc analysis, the percentage of change in STR, MBG, angina relief after pPCI, and cTFC was significantly higher in the prasugrel group (p<0.017). Conclusion: In STEMI patients undergoing pPCI, the analysis of tissue level reperfusion parameters indicates a superior effect of prasugrel compared with other P2Y12 inhibitors used to achieve reperfusion.
dc.identifier.doi10.2478/jce-2020-0018
dc.identifier.endpage97
dc.identifier.issn2457-5518
dc.identifier.issn2457-550X
dc.identifier.issue4
dc.identifier.startpage91
dc.identifier.urihttps://doi.org/10.2478/jce-2020-0018
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30250
dc.identifier.volume6
dc.identifier.wosWOS:000605690900004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherSciendo
dc.relation.ispartofJournal of Cardiovascular Emergencies
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectP2Y12 inhibitors
dc.subjectST segment resolution
dc.subjectTIMI frame count
dc.subjectmyocardial blush grade
dc.titleEffectiveness of Different P2Y12 Inhibitors on Coronary Flow in Patients with ST-Elevation Myocardial Infarction
dc.typeArticle

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