Increased Circulating Fetuin-A Levels in Patients with Atrial Fibrillation

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dc.contributor.authorTekin, Gülaçan
dc.contributor.authorTekin, Yusuf Kenan
dc.contributor.authorAydın, Hüseyin
dc.contributor.authorNur, Naim
dc.date.accessioned2024-10-26T17:52:57Z
dc.date.available2024-10-26T17:52:57Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground: Biomarkers related to the pathogenesis of atrial fibrillation (AF) have attracted the attention of experts. One of these recently studied biomarkers is Fetuin-A. Objectives: This study aimed to evaluate the relationship between serum Fetuin-A levels and AF. Methods: This study used the convenience sampling method, based on inclusion criteria and consent to participate in the study. The Shapiro-Wilk test was used to confirm the normal distribution of all continuous variables. Categorical variables were presented using absolute and relative frequencies. Both groups (48 patients with AF and 47 controls) were compared in terms of biochemical, hematological, and echocardiographic findings and Fetuin-A. the Chi-square or Fisher's exact test were used to compare groups concerning categorical variables. Continuous variables were compared using the independent samples t-test. P<0.05 was considered statistically significant. Results: Serum Fetuin-A values increased in AF patients when compared to the controls (544±49 ?g/mL versus 484±46 ?g/mL, p=0.001). Moreover, Fetuin-A level was independently associated with AF — AOR = 0.978, 95%; confidence interval (CI) 0.969-988, p < 0.001. The cut-off values in Fetuin-A levels in patients with AF were >511.80 ?g/mL with a sensitivity of 75% and a specificity of 73% — area under the curve (AUC) = 0.804, 95% CI = 0.715-0.892. Conclusions: According to this study, there was a relationship between serum Fetuin-A levels and AF, regardless of conventional cardiovascular risk factors. Therefore, Fetuin-A may play a role in the pathophysiology of AF. Prospectively designed cohort studies are necessary to assess whether or not the results can be generalized for other populations. © 2024, Sociedade Brasileira de Cardiologia. All rights reserved.
dc.identifier.doi10.36660/ijcs.20220174
dc.identifier.issn2359-4802
dc.identifier.scopus2-s2.0-85199283234
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.36660/ijcs.20220174
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26603
dc.identifier.volume37
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSociedade Brasileira de Cardiologia
dc.relation.ispartofInternational Journal of Cardiovascular Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectalfa-2-Glicoproteína-HS; Atrial fibrillation; Inflammation
dc.titleIncreased Circulating Fetuin-A Levels in Patients with Atrial Fibrillation
dc.typeArticle

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