Successful treatment of intoxication case with rosiglitasone and metformin

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dc.contributor.authorDüger, Cevdet
dc.contributor.authorIsbir, Ahmet Cemil
dc.contributor.authorÖzdemir Kol, Iclal
dc.contributor.authorKaygusuz, Kenan
dc.contributor.authorGürsoy, Sinan
dc.contributor.authorKiliç, Isa
dc.contributor.authorMimaro?lu, Caner
dc.date.accessioned2024-10-26T17:53:27Z
dc.date.available2024-10-26T17:53:27Z
dc.date.issued2013
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractMetformin is a biguanide antidiabetic high doses of which may cause lactic acidosis. Rosiglitazone is a member of thiazolidinedione antidiabetics group which increases insulin sensitivity. A 35-year-old female patient was admitted to hospital with the complaints of loss of consciousness, oliguria, nausea and vomiting after a history of 48 g of metformin, 108 mg rosiglitasone uptake for suicide. Hypotension, hypoglycemia and metabolic acidosis were observed in the patient, sos he was supported by mechanical ventilation due to the Glasgow coma scale 5. The patient was discharged liome on the 45th day after continuous venovenous hemodiafdtration, supplamentary treatment and 39 days of mechanical ventilation support. There must be a suspicion for metformin intoxication in the patients with high anionic gap metabolic acidosis, and who take overdose drugs for suicide. Since metformin associated hypoglycemia, lactic acidosis and hypothermia are reversible, early diagnosis of metabolic acidosis and cardiovascular support with hemodialysis and hemofdtraiion protect blood glucose level and body temperature, which allow for possible recovery.
dc.identifier.endpage193
dc.identifier.issn1300-0578
dc.identifier.issue3
dc.identifier.scopus2-s2.0-84882423858
dc.identifier.scopusqualityQ4
dc.identifier.startpage190
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26965
dc.identifier.volume21
dc.indekslendigikaynakScopus
dc.language.isotr
dc.relation.ispartofAnestezi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectContinuous venovenous hemodiafdtration; Intoxication; Metformin; Rosiglitasone
dc.titleSuccessful treatment of intoxication case with rosiglitasone and metformin
dc.title.alternativeRosi?gli?tazon ve metformi?n i?le zehi?rlenme olgusunun başari?li? tedavi?si?
dc.typeArticle

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