Cytotoxic effect of azole compounds bearing trifluorophenyl ring on MCF-7, MDA-MB-231, and HCT-116 cancer cell line

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dc.contributor.authorAlagöz, Mehmet
dc.contributor.authorÖzdemir, Zeynep
dc.contributor.authorKarakurt, Arzu
dc.contributor.authorHepokur, Ceylan
dc.date.accessioned2024-10-26T17:44:03Z
dc.date.available2024-10-26T17:44:03Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractCancer, a disease defined by rapid proliferation of cells, still remains one of the most feared diseases of the modern world. Many structurally different anti-carcinogenic drugs are used in several tumor types such as bladder, colon, ovary, breast, head and neck, testis, lung and prostate cancer. In this study, cytotoxic effects of the compounds with different linkers (ketone, oxime, alcohol, chlorine) between pyrazole and trifluoromethyl on MCF-7 (human breast adenocarcinoma), MDA-MB-231 (human breast adenocarcinoma), and HCT-116 (human colon cancer) cell lines were investigated. Compound a1 was observed to be the most potent compound with IC50 values of 5.84±0.76, 5.01±0.32, 5.57±0.02 µg.ml-1 against these cell lines, respectively. It was found that all compounds were very effective against all the tested cancer cell lines.
dc.identifier.doi10.5455/medscience.2022.04.085
dc.identifier.endpage1216
dc.identifier.issn2147-0634
dc.identifier.issue3
dc.identifier.startpage1212
dc.identifier.trdizinid1131323
dc.identifier.urihttps://doi.org/10.5455/medscience.2022.04.085
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1131323
dc.identifier.urihttps://hdl.handle.net/20.500.12418/25085
dc.identifier.volume11
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofMedicine Science
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleCytotoxic effect of azole compounds bearing trifluorophenyl ring on MCF-7, MDA-MB-231, and HCT-116 cancer cell line
dc.typeArticle

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