The effects of sildenafil in liver and kidney injury in a rat model of severe scald burn: A biochemical and histopathological study

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dc.contributor.authorGökakin, Ali Kağan
dc.contributor.authorAtabey, Mustafa
dc.contributor.authorDeveci, Koksal
dc.contributor.authorSancakdar, Enver
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorDuger, Cevdet
dc.contributor.authorTopcu, Omer
dc.date.accessioned2024-10-26T17:53:07Z
dc.date.available2024-10-26T17:53:07Z
dc.date.issued2014
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground: Severe burn induces systemic inflammation and reactive oxygen species leading to lipid peroxidation which may play role in remote organs injury. Sildenafil is a selective and potent inhibitor of cyclic guanosine monophosphate specific phosphodiesterase- 5. Sildenafil reduces oxidative stress and inflammation in distant organs. The aim of the present study was to evaluate the effects of different dosages of sildenafil in remote organs injury.; Methods: A total of thirty-two rats were randomly divided into four equal groups. The groups were designated as follows: Sham, Control, 10, and T20 mg/kg sildenafil treatment groups. Levels of malondialdehyde (MDA), vascular endothelial growth factor (VEGF), VEGF receptor (Flt-1), activities of glutathione peroxidase (Gpx), levels of total antioxidative capacity (TAC), and total oxidant status (TOS) were measured in both tissues and serum, and a semi-quantitative scoring system was used for the evaluation of histopathological findings.; Results: Sildenafil increased levels of Gpx, and Flt-1, and decreased MDA and VEGF levels in tissues. Sildenafil also increased serum levels of TAC and Flt-1 and decreased TOS, OSI, and VEGF.; Conclusion: Sildenafil decreased inflammation scores in remote organs in histopathological evaluation. It has protective effects in severe burn-related remote organ injuries by decreasing oxidative stress and inflammation. © 2014, TJTES.
dc.identifier.doi10.5505/tjtes.2014.39586
dc.identifier.endpage327
dc.identifier.issn1306-696X
dc.identifier.issue5
dc.identifier.pmid25541842
dc.identifier.scopus2-s2.0-84908029692
dc.identifier.scopusqualityQ2
dc.identifier.startpage319
dc.identifier.urihttps://doi.org/10.5505/tjtes.2014.39586
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26732
dc.identifier.volume20
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Association of Trauma and Emergency Surgery
dc.relation.ispartofUlusal Travma ve Acil Cerrahi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRemote organ injury; Scald burn; Sildenafil
dc.titleThe effects of sildenafil in liver and kidney injury in a rat model of severe scald burn: A biochemical and histopathological study
dc.title.alternativeSildenafilin ağır haşlama yanığı oluşturulan sıçan modelinde karaciğer ve böbrek hasarı üzerine etkisi: Biyokimyasal ve histopatolojik çalışma
dc.typeArticle

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