Protein pump inhibitors esomeprazole and pantoprazole increase the chemosensitivity of Cml cells against imatinib

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dc.contributor.authorErgül, Merve
dc.contributor.authorErgül, Mustafa
dc.date.accessioned2024-10-26T17:44:19Z
dc.date.available2024-10-26T17:44:19Z
dc.date.issued2018
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: Proton pump inhibitors (PPIs) largely used drug to treat gastroesophageal disease such as gastric ulcers.Moreover, in recent years, several studies suggest that PPIs have important anti-cancer effect in monotherapy and orcombination with chemotherapy.The aim of this study was to investigate whether esomeprazole and pantoprazole exhibit anti-cancer effect alone orcould enhance chemosensitivity of CML cell line K562 to imatinib.Method: Human chronic myeloid leukemia (CML) cells were cultured and treated with different concentrations ofesomeprazole, pantoprazole, and imatinib alone. Also these cells exposed to imatinib + esomeprazole and imatinib +pantoprazole combinations, respectively and incubated 24 h. The antiproliferative activities of the (PPIs) alone or incombination of imatinib was evaluated using the XTT colorimetric assay.Results: According to experimental data, neither PPIs showed any cytotoxicity on the K562 cell line at allconcentrations except at 500 and 1000 ?M. However, when combined with imatinib separately, they were found to havesignificant anti-cancer effects on K562 cells when compared to cell lines treated with imatinib alone (p<0.05).Conclusions: Taken together, the inhibition of V-ATPase via esomeprazole and pantoprazole might enhance thechemosensitivity of imatinib in CML cells. However, further studies are needed to be able to utilize PPIs in CML.
dc.identifier.doi10.7197/223.vi.499367
dc.identifier.endpage355
dc.identifier.issn1305-0028
dc.identifier.issue4
dc.identifier.startpage351
dc.identifier.trdizinid321939
dc.identifier.urihttps://doi.org/10.7197/223.vi.499367
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/321939
dc.identifier.urihttps://hdl.handle.net/20.500.12418/25207
dc.identifier.volume40
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofCumhuriyet Tıp Dergisi (ELEKTRONİK)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCerrahi
dc.titleProtein pump inhibitors esomeprazole and pantoprazole increase the chemosensitivity of Cml cells against imatinib
dc.typeArticle

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