Investigation of the relationship between ?2- adrenergic receptor (?2-AR) polymorphism and gastric cancer

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dc.contributor.authorAtabey, Mustafa
dc.contributor.authorTaş, Ayça
dc.contributor.authorAğbektaş, Tuğba
dc.contributor.authorBostancı, Meriç Emre
dc.contributor.authorTopçu, Ömer
dc.contributor.authorSiliğ, Yavuz
dc.date.accessioned2024-10-26T17:44:19Z
dc.date.available2024-10-26T17:44:19Z
dc.date.issued2018
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: Gastric cancer is a multifunctional disease. Emotional stress, physiological and neuroendocrine changes incancer patients can lead to the activation of the hypothalamic-pituitary-adrenal axis and the release of hormonedependent hormones such as catecholamine. In particular, it has been reported that catecholamine induction directlyaffects the biological behavior of tumor cells via ?2-Adrenergic receptor (?2-AR) mediated signaling. In this study, itwas aimed to investigate polymorphism of ?2-AR gene (rs1042717) in gastric cancer patients.Method: Polymorphism in the ?2-AR gene (rs1042717) was determined by Real-Time PCR method in 60 gastric cancerpatients and 50 healthy controls. The results were evaluated using logistic regression and Chi-square (?2) test.Results: The comparison of gastric cancer patients and controls determined a statistically significant relationship foralcoholic drink consumption (p<0,05). There was a statistically significant relationship between ?2-AR (rs1042717)polymorphism and stomach cancer (p <0.05). There was a statistically significant relationship between mutant (AA)genotype with wild type (GG) and heterozygous (AG) polymorphic genotypes when evaluated in ?2-AR polymorphismgastric cancer patients and control group (?2: 19,38, p: 0.001). Similarly, there was a statistically significant correlationbetween heterozygous (AG) with wild type (GG) and mutant (AA) polymorphic genotypes in gastric cancer (?2: 14, 27,p: 0,001).Conclusions: In this study, it was found that the AG genotype is predominant in gastric cancer patients and controls,and that the AA genotype has a protective effect against gastric cancer.
dc.identifier.doi10.7197/223.vi.431429
dc.identifier.endpage290
dc.identifier.issn1305-0028
dc.identifier.issue3
dc.identifier.startpage284
dc.identifier.trdizinid326293
dc.identifier.urihttps://doi.org/10.7197/223.vi.431429
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/326293
dc.identifier.urihttps://hdl.handle.net/20.500.12418/25196
dc.identifier.volume40
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofCumhuriyet Tıp Dergisi (ELEKTRONİK)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCerrahi
dc.titleInvestigation of the relationship between ?2- adrenergic receptor (?2-AR) polymorphism and gastric cancer
dc.typeArticle

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