Concomitant substance use increases the toxic effect of synthetic cannabinoid (Bonsai): A prospective study

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dc.contributor.authorBeydilli, İnan
dc.contributor.authorDuyan, Murat
dc.contributor.authorYılmaz, Fevzi
dc.contributor.authorArslan, Engin Deniz
dc.contributor.authorKorkmaz, İlhan
dc.contributor.authorAkçimen, Mehmet
dc.contributor.authorKeşaplı, Mustafa
dc.date.accessioned2024-10-26T17:52:48Z
dc.date.available2024-10-26T17:52:48Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: In this study, we aimed to contribute to the literature by evaluating synthetic cannabinoid (bonsai) and additional drugs. Materials and Methods: This prospective study was conducted on 217 patients who admitted to the emergency department (ED) with bonsai intake between December 20, 2014 and Janu-ary 1, 2016, according to the patient history obtained from the patients. One hundred sixty-eight patients with negative urinary metabolites results were excluded from the study, 49 patients with positive urinary metabolites were included in the study. Patients were divided into two groups. The first group consisted of patients with only bonsai intake and the second group consisted of patients with bonsai and concomitant drug intake. The groups were compared in terms of symptoms, findings, blood gas values, duration of the symp-toms, discharge time, hospitalization, and mortality rate. Data were analyzed using the Chi-square, the Fish-er’s exact test, the Student t-test, and the Mann-Whitney U test. Data were evaluated at the 95% confidence interval. P<0.05 was considered statistically significant. Results: The mean age of 49 patients included in the study was 26.7±8.9 years and 91.8% (n=45) of the patients were male. Concomitant drug intake was identified in 69.4% of the patients. Concomitant drug use was as follows: cocaine (20.4%, n=10), amphetamines (14.3%, n=7), methamphetamines (8,2%, n=4,) tetrahydrocannabinol (32.7%, n=16), opiates (18.4%, n=9) and alcohol (30.6%, n=15). On admission, the Glasgow Coma Score (GCS) in the bonsai group with an additional substance was significantly higher (p=0,003). The most common symptom was palpitations (tachycardia) (75.5%, n=37). There were no patients hospitalized in the Only Bonsai group (p=0,020). The median time to remission of symptoms and median follow-up time of the patients in the emergency room were 3 hours and 6 hours, respectively. Remission time of the symptoms and hospitalization rates were higher in patients taking concomitant drug (p <0.05). Conclusion: While the bonsai intake alone is not considered mortal to the patients and most of them can be discharged from the ED after signs and symptoms disappear, concomitant drug use can increase the toxic effects of bonsai intake. That is why the follow-up of patients taking concomitant drugs, and the treatment process should be carried out more carefully. (www.actabiomedica.it). © Mattioli 1885.
dc.identifier.doi10.23750/abm.v92i1.9989
dc.identifier.endpage10
dc.identifier.issn0392-4203
dc.identifier.issue1
dc.identifier.pmid33682827
dc.identifier.scopus2-s2.0-85102697430
dc.identifier.scopusqualityQ3
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.23750/abm.v92i1.9989
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26524
dc.identifier.volume92
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMattioli 1885
dc.relation.ispartofActa Biomedica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBonsai; Substance abuse; Toxic effect
dc.titleConcomitant substance use increases the toxic effect of synthetic cannabinoid (Bonsai): A prospective study
dc.typeArticle

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