Evaluation of Ki-67 Immunostaining in the Differential Diagnosis of Low Grade Squamous Intraepithelial Lesion and Normal Cervix

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dc.contributor.authorArici, Sema Dilek
dc.contributor.authorImir, Gonca
dc.contributor.authorOzer, Hatice
dc.contributor.authorElagoz, Sahande
dc.contributor.authorSimsek, Gulay
dc.contributor.authorCetin, Meral
dc.date.accessioned2024-10-26T18:03:52Z
dc.date.available2024-10-26T18:03:52Z
dc.date.issued2007
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: Ki-67 immunostaining is used as an adjunct in the differential diagnosis of squamous intraepithelial lesions (SILs) of the cervix. The aim of this study was to determine an index for positive Ki-67 staining and the Ki 67-positive cell clusters for distinguishing normal cervix and low-grade squamous intraepithelial lesions (low-grade SILs). Materials and Methods: Thirty-four cervical specimens, in which 17 were previously diagnosed as normal and 17 low-grade SILs were included in the study. Ki-67 immunohistochemical staining was performed using avidin biotin complex. Results: After reevaluating the cases by means of histo-pathological and Ki-67 immunostaining features, 21 of 34 cases were diagnosed as normal cervix and 13 were diagnosed as low-grade SILs. Ki-67 index was higher in low-grade SILs (p<0.05). Although Ki-67 positive cell clusters was not observed in normal cervix, 77% of 13 low-grade SILs had positive cell clusters (p<0.05). Discussion: Ki-67 immunostaining may be considered as an easy and reproducible technique in differential diagnosis of normal cervix and low-grade SIL.
dc.identifier.endpage289
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.issue3
dc.identifier.startpage285
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28622
dc.identifier.volume8
dc.identifier.wosWOS:000420589100007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherGalenos Yayincilik
dc.relation.ispartofJournal of the Turkish-German Gynecological Association
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcervix
dc.subjectKi-67
dc.subjectimmunohistochemistry
dc.subjectlow-grade squamous intraepithelial lesion
dc.titleEvaluation of Ki-67 Immunostaining in the Differential Diagnosis of Low Grade Squamous Intraepithelial Lesion and Normal Cervix
dc.typeArticle

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