Xanthine oxidase, adenosine deaminase and vitamin e levels in patients with schizophrenia

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dc.contributor.authorKiliçgün, Hasan
dc.contributor.authorErşan, Etem Erdal
dc.contributor.authorBakir, Sevtap
dc.contributor.authorErşan, Serpil
dc.contributor.authorKoç, Derya
dc.contributor.authorDemirpençe, Özlem
dc.contributor.authorDoğan, Kübra
dc.date.accessioned2024-10-26T17:53:06Z
dc.date.available2024-10-26T17:53:06Z
dc.date.issued2016
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: Neuronal damage caused by free radicals is believed to be effective in pathogenesis of several psychi-atric disorders. This belief is due to the toxic effects of free radicals that play a role in oxidative stress. Considering that the brain is one of the most sensitive organs to the oxidative damage, the importance of oxidative stress in psychiatric disorders will become more apparent. Additionally, high oxygen use in the brain, and its structure rich in lipid, which is one of the most sensitive molecules to the free radical damage, and its having the average antioxi-dant system yield support oxidative stress theory in the pathogenesis of psychiatric disorders. This study aimed to determine xanthine oxidase (XO), adenosine deaminase (ADA) and vitamins E levels in patients with schizophrenia and control groups, and to investigate the relationship between schizophrenia and the parameters by comparing the measured parameters with each other. Methods: Our study sample included 30 patients diagnosed with schizo-phrenia. The control group consisted of 30 healthy volunteers matched by sex with similar age and smoking habits. In the patient group and the control group, adenosine deaminase, xanthine oxidase, and vitamin E were measured manually using spectrophotometric methods. Results: Serum xanthine oxidase levels in the schizophrenic group were significantly higher than the control group levels. Serum vitamin E and adenosine deaminase levels in the schizophrenia group were significantly lower than the levels of the control group. Discussion and Conclusion: The fact that mechanism of schizophrenia pathogenesis which has a wide variety of clinical symptoms and a dis-ease process is yet to be elucidated reveals the importance of this kind of studies. In this study, low levels of antioxidant vitamin E and adenosine deaminase, and high levels of xanthine oxidase suggest that oxidative stress-mediated neuronal damage may play a role in the pathogenesis of schizophrenia. Therefore, we believe that further research with larger sample groups should be conducted. © 2016, Cukurova University, Faculty of Medicine. All rights reserved.
dc.identifier.doi10.5455/apd.214492
dc.identifier.endpage481
dc.identifier.issn1302-6631
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85006751047
dc.identifier.scopusqualityQ4
dc.identifier.startpage476
dc.identifier.urihttps://doi.org/10.5455/apd.214492
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26730
dc.identifier.volume17
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherCukurova University, Faculty of Medicine
dc.relation.ispartofAnadolu Psikiyatri Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdenosine deaminase; Schizophrenia; Vitamin E; Xanthine oxidase
dc.titleXanthine oxidase, adenosine deaminase and vitamin e levels in patients with schizophrenia
dc.title.alternativeŞizofreni hastalarında ksantin oksidaz, adenozin deaminaz ve E vitamini düzeyleri
dc.typeArticle

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