Determination of Serum Cathepsin G Level in Patients with Multiple Myeloma

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dc.contributor.authorTerzi, Hatice
dc.date.accessioned2024-10-26T17:34:05Z
dc.date.available2024-10-26T17:34:05Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractMultiple myeloma is a hematological malignancy identified by bone marrow infiltration of clonal plasma cells. It is still not a curable disease under current conditions. Cathepsin G is a serine protease playing a role in inflammation that is present in the azurophilic granules of neutrophils. It is known that there is a relationship between Cathepsin G and chronic inflammatory diseases and tumors. The goal of the study is to define its role in multiple myeloma. In the study, 33 patients newly diagnosed with MM who were never received treatment and 33 control subjects were included. Basic laboratory parameters and Cathepsin G levels were examined both in the myeloma patient group and control group. While the serum CathG level in the control group is 22.84 ng/mL, the serum CathG level of the MM patient group is 10.77 ng/mL. Serum CathG level in the control group is statistically significantly higher than the MM patient group. The aim of the present study is to contribute to the literature in hematological malignancies, to figure out the role of Cathepsin G in multiple myeloma, and to open a door to new treatment options for multiple myeloma, which is an incurable disease, yet.
dc.identifier.doi10.17776/csj.1453805
dc.identifier.endpage267
dc.identifier.issn2587-2680
dc.identifier.issn2587-246X
dc.identifier.issue2
dc.identifier.startpage263
dc.identifier.trdizinid1246078
dc.identifier.urihttps://doi.org/10.17776/csj.1453805
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1246078
dc.identifier.urihttps://hdl.handle.net/20.500.12418/23510
dc.identifier.volume45
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofCumhuriyet Science Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectInflammation
dc.subjectMultiple myeloma
dc.subjectCathepsin G
dc.titleDetermination of Serum Cathepsin G Level in Patients with Multiple Myeloma
dc.typeArticle

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