Ozone improves autogenous graft healing in experimental diabetes mellitus: A morphometric and immunohistochemical study

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dc.contributor.authorAlpan, Aysan Lektemur
dc.contributor.authorToker, Hülya
dc.contributor.authorÖzer, Hatice
dc.date.accessioned2024-10-26T17:33:39Z
dc.date.available2024-10-26T17:33:39Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground: Diabetes mellitus (DM) is a metabolic disorder whichplays crucial role in the pathogenesis of periodontitis. Ozone haveseveral actions such as antimicrobial, immunostimulating,antihypoxic effects, and activates antioxidant enzymes andangiogenesis. The aim of this study is to investigate the effect ofgaseous ozone on bone healing in diabetic rat calvarial defectstreated with autogenous bone graft, morphometrically andimmunohistochemically.Material and Methods: Diabetes was induced and critical sizedefects were created on rats. Study groups: 1-Empty defect(Control, n=14) group, 2-Autograft (AG, n=14) group, 3-Emptydefect+ozone therapy (Control+Ozone, n=14) group, 4-Autograft+ozone application (AG+Ozone, n=14) group. Gaseousozone was applied on the operation day and the following 2 weeksdaily (140ppm @ 2L/d, 2.24 mg). Total bone area was measured.Osteocalcin and Bone morphogenic protein-2 protein expressionswere evaluated.Results: Control and Control+Ozone groups had no osteoclastand residuel lacunae during the study . Osteoblasts in AG+Ozonegroup were higher than AG group at 4th week (p>0.05).AG+Ozone group had more total bone area than AG group at 4thweek. AG+Ozone group revealed more BMP-2 immune positivitycompared to the other groups. Osteocalcin immune positivity inAG groups was higher than those of the Control groups.Conclusion: Within the limitations of this study, gaseous ozoneapplication decreased osteoclast number and increasedosteoblast number and bone regeneration, especially, in earlystages of bone regeneration in diabetic rats
dc.identifier.doi10.15311/selcukdentj.419582
dc.identifier.endpage53
dc.identifier.issn2148-7529
dc.identifier.issue1
dc.identifier.startpage44
dc.identifier.trdizinid368831
dc.identifier.urihttps://doi.org/10.15311/selcukdentj.419582
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/368831
dc.identifier.urihttps://hdl.handle.net/20.500.12418/23243
dc.identifier.volume7
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofSelcuk Dental Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleOzone improves autogenous graft healing in experimental diabetes mellitus: A morphometric and immunohistochemical study
dc.typeArticle

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