Expression of p16 Protein and Cyclin D1 in Periampullary Carcinomas

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dc.authoridDemirkan, Nese/0000-0001-5860-100X
dc.contributor.authorTuncer, Ersin
dc.contributor.authorTurk, Nilay Sen
dc.contributor.authorArici, Sema
dc.contributor.authorDuzcan, Suleyman Ender
dc.contributor.authorDemirka, Nese Calli
dc.date.accessioned2024-10-26T18:08:10Z
dc.date.available2024-10-26T18:08:10Z
dc.date.issued2011
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: The majority of the tumors in periampullary region are pancreatic and ampulla of Vater carcinomas. The aim of this study was to compare histopathological features of ampulla of Vater carcinomas with pancreatic ductal adenocarcinomas and to determine diagnostic and predictive values of p16 protein and cyclin D1 expression. Material and Method: Tissue samples from pancreatic ductal adenocarcinomas and ampulla of Vater carcinomas were obtained from 31 patients who underwent pancreticoduodenectomy for periampullary carcinoma. The study group was composed of 12 women and 19 men. Their median age was found to be 62.32 years (range 26-85 years). The parameters analyzed in the study included lymph node metastases, perineural invasion, differentiation, duodenal invasion, grade of intraepithelial neoplasia and p16 and cyclinD1 expression in tumoral and peritumoral pancreatic tissues. Results: In both tumor groups, the loss of p16 protein expression was significantly correlated with perineural invasion (p= 0.0001). Perineural invasion was more frequent in the pancreatic ductal adenocarcinoma group than the ampulla of Vater carcinoma group (p= 0,01). When desmoplasia and lymphoplasmacytic stromal infiltration were examined, desmoplastic reaction was significantly higher in pancreatic ductal adenocarcinomas than ampulla of Vater carcinomas (p= 0.01). No significant difference was observed between tumor groups for Cyclin D1 (p> 0.05). Conclusion: The results suggest that loss of p16 protein expression may be a sign for poor prognosis in periampullary cancers that is correlated mainly with perineural invasion. Desmoplastic stromal reaction may be a distinctive feature for pancreatic ductal adenocarcinoma compared with ampulla of Vater carcinoma.
dc.identifier.doi10.5146/tjpath.2011.01007
dc.identifier.endpage22
dc.identifier.issn1018-5615
dc.identifier.issn1309-5730
dc.identifier.issue1
dc.identifier.pmid21469422
dc.identifier.startpage17
dc.identifier.urihttps://doi.org/10.5146/tjpath.2011.01007
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29846
dc.identifier.volume27
dc.identifier.wosWOS:000217437300004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherFederation Turkish Pathology Soc
dc.relation.ispartofTurkish Journal of Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCarcinoma
dc.subjectp16
dc.subjectCyclin D1
dc.subjectAmpulla of Vater
dc.subjectHistopathology
dc.subjectPancreatic ductal carcinoma
dc.titleExpression of p16 Protein and Cyclin D1 in Periampullary Carcinomas
dc.typeArticle

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