The effect of penicillin-induced epileptiform activity on proinflammatory cytokines levels in the rat brain

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dc.contributor.authorFiliz, Ahmet Kemal
dc.contributor.authorKarabulut, Sebahattin
dc.date.accessioned2024-10-26T17:34:08Z
dc.date.available2024-10-26T17:34:08Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractEmerging evidence indicates a pathogenic role of protracted neuroinflammation in the various neurodegenerative diseases, including epilepsy. Neuroinflammation may contribute to neuronal hyperexcitability underlying seizure formation. The current research aims to examine the changes in the levels of proinflammatory cytokines such as interleukin-1? (IL-1?) and tumor necrosis factor-? (TNF-?) in the penicillin epilepsy model. In the present study, 12 male Wistar albino rats were randomly divided into two groups as sham and penicillin epilepsy model. Seizures were induced with the intracortical (i.c.) single microinjection 500 IU of penicillin-G into neocortex. Rats were decapitated after observing the cortical epileptic activity and brains were removed by craniotomy. Proinflammatory cytokines (TNF-? and IL-1?) were measured by using ELISA methods in the cortical and hippocampal brain regions. Penicillin significantly up-regulated the expression of IL 1? and TNF-? in the rat cortex, but did not affect the hippocampal cytokines levels. This study is indicative of the neuroinflammatory potential of cortical penicillin administration.
dc.identifier.doi10.17776/csj.775122
dc.identifier.endpage6
dc.identifier.issn2587-2680
dc.identifier.issn2587-246X
dc.identifier.issue1
dc.identifier.startpage1
dc.identifier.trdizinid1120612
dc.identifier.urihttps://doi.org/10.17776/csj.775122
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1120612
dc.identifier.urihttps://hdl.handle.net/20.500.12418/23551
dc.identifier.volume42
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofCumhuriyet Science Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleThe effect of penicillin-induced epileptiform activity on proinflammatory cytokines levels in the rat brain
dc.typeArticle

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