SYNTHESIZE AND STABILITY ANALYSIS OF PEGYLATED NANOGRAPHENE OXIDE FOR DELIVERY OF DOXORUBICIN

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dc.contributor.authorCakmak, Nese Keklikcioglu
dc.contributor.authorTezel, Guler Bengusu
dc.date.accessioned2024-10-26T18:06:03Z
dc.date.available2024-10-26T18:06:03Z
dc.date.issued2019
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIn this study, graphene oxide nanoparticle (NGO) was fabricated via modified Hummers' method and then modified with amine terminated 4-armed PEG to enhance the biocompatibility and stability of nano drug carrier. In our strategy, Doxorubicin (DOX) was used as a model drug. DOX loading onto NGO-PEG was synthesized by simply mixing with the NGO-PEG solution at pH 7 overnight. NGO, NGO-PEG and NGO-PEG-DOX was characterized by power X-ray diffraction, scanning electron microscopy, and UV spectroscopy. Stability analysis was performed with zeta potential. The experimental results showed that the zeta potential analysis values were above +/- 40 mV. NGO-PEG-DOX is still had very good dispersion stability even after 45 days. Therefore, this drug loaded product can be good candidate for treatment of cancer.
dc.description.sponsorshipScientific Research Project Fund of Sivas Cumhuriyet University [M-720]
dc.description.sponsorshipThe authors acknowledge the financial support provided by the Scientific Research Project Fund of Sivas Cumhuriyet University under the project number M-720.
dc.identifier.endpage351
dc.identifier.issn1583-3186
dc.identifier.issue3
dc.identifier.startpage346
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29339
dc.identifier.volume49
dc.identifier.wosWOS:000487262400005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherSerban Solacolu Foundation
dc.relation.ispartofRevista Romana De Materiale-Romanian Journal of Materials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectnanographene oxide (NGO)
dc.subjectnanostructured drug carrier
dc.subjectstability
dc.subjectDOX
dc.subjectPEGylated
dc.titleSYNTHESIZE AND STABILITY ANALYSIS OF PEGYLATED NANOGRAPHENE OXIDE FOR DELIVERY OF DOXORUBICIN
dc.typeArticle

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