Anti-adhesive effect of naturally obtained dicalcium phosphate dihydrate nanoparticles in the rat uterine wound model

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dc.contributor.authorKurt, Begum
dc.contributor.authorOksuz, Kerim E.
dc.contributor.authorSahin-Inan, Zeynep D.
dc.contributor.authorHepokur, Ceylan
dc.date.accessioned2024-10-26T17:52:49Z
dc.date.available2024-10-26T17:52:49Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: In this study, we aimed to compare the anti-adhesive effects of contractubex and dicalcium phosphate dihydrate (DCPD) particles in rats treated with the uterine horn adhesion model. Materials and methods: Newly adult, 60 Wistar albino rats were used as experimental animals. The modified rat uterine horn adhesion model was used to induce intra-abdominal adhesion. Tumor necrosis factor (TNF)-?, interleukin (IL)-1, vascular endothelial growth factor (VEGF) and transforming growth factor (TGF)-?1 were studied for biochemical and immunohistochemical examination. Results: TNF-? decreased in each group, while it decreased more in G2 and G3 than in G1. IL-1? decreased in each group, while it decreased the most in G3. TGF-?1 and VEGF localization was less in the G2 compared to G1, the least TGF-?1 and VEGF immunolocalization was detected in the G3 and G4. For both antibodies, the least localization among all groups belonged to G3. From day 7 to day 21, the highest TGF-?1 immunolocalization was observed in G1, lesser localization in G2 and lowest in G3. Conclusion: DCPD nanoparticles show promise as a clinical antiadhesive agent and should be further evaluated in experimental animal models and human trials. © 2023 Academia Mexicana de Cirugía.
dc.description.sponsorshipSivas Cumhuriyet Üniversitesi, (2021 T-910)
dc.identifier.doi10.24875/CIRU.23000097
dc.identifier.endpage467
dc.identifier.issn0009-7411
dc.identifier.issue4
dc.identifier.pmid37677953
dc.identifier.scopus2-s2.0-85170172437
dc.identifier.scopusqualityQ4
dc.identifier.startpage457
dc.identifier.urihttps://doi.org/10.24875/CIRU.23000097
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26540
dc.identifier.volume91
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPermanyer Publications
dc.relation.ispartofCirugia y Cirujanos (English Edition)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDicalcium phosphate dihydrate; Gynecologic surgery; Nanoparticles; Wistar rats
dc.titleAnti-adhesive effect of naturally obtained dicalcium phosphate dihydrate nanoparticles in the rat uterine wound model
dc.title.alternativeEfecto antiadhesivo de nanopartículas de dihidrato de fosfato dicálcico obtenidas naturalmente en el modelo de herida uterina de rata
dc.typeArticle

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