Effect of Astragalus microcephalus wild extract and Vitamin E–Selenium combination on Cadmium–induced damage in rat ovaries

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dc.contributor.authorKurt, Begum
dc.contributor.authorKara, Haki
dc.contributor.authorSahın, Mahmut
dc.contributor.authorKumru, Alper Serhat
dc.contributor.authorOzkaraca, Mustafa
dc.date.accessioned2025-05-04T16:41:53Z
dc.date.available2025-05-04T16:41:53Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThis study was conducted to investigate the protective effect of Astragalus (AST) extract alone and in combination with vitamin E (vit E) + selenium (Se) against the toxicity induced by cadmium (CdCl2) in rat ovaries. Thirty–six female Wistar rats were divided into six groups. AST was administered at a dose of 5 mg·kg-1, Cd at a dose of 2 mg·kg-1, and Vit E (60 mg·kg-1) + Se (1 mg·kg-1) orally for a duration of 15 days. The levels of MDA, GSH–Px, SOD, and CAT were analyzed in the blood and tissue samples to assess oxidative stress. Additionally, the levels of estrogen, FSH, LH, Inhibin B, and Antimullerian hormones were measured in the serum samples. The ovarian tissues were examined histopathologically and immunohistochemically for 8–OhDG, Caspase 3, and LC3B immunoreactivity. In the group exposed to CdCl2, MDA levels significantly increased, while antioxidant parameters showed significant decreases (P<0.05). Although significant improvements were observed in the groups treated with AST alone, more significant improvements were seen in the groups treated with both AST and Vit E + Se (P<0.05). It was concluded that AST extracts alone and in combination with Vit E + Se exhibited protective effects against ovarian toxicity caused by Cd exposure and may be effective against metal toxicity. © (2024), (Universidad del Zulia, Facultad de Ciencias Veterinarias). All rights reserved.
dc.description.sponsorshipSivas Cumhuriyet Üniversitesi, (V–2021–119)
dc.identifier.doi10.52973/RCFCV-E34449
dc.identifier.issn0798-2259
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85214428703
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.52973/RCFCV-E34449
dc.identifier.urihttps://hdl.handle.net/20.500.12418/34950
dc.identifier.volumeXXXIV
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniversidad del Zulia, Facultad de Ciencias Veterinarias
dc.relation.ispartofRevista Cientifica de la Facultad de Veterinaria
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250504
dc.subjectAstragalus
dc.subjectCadmium
dc.subjectovarium damage
dc.subjectoxidative stress
dc.titleEffect of Astragalus microcephalus wild extract and Vitamin E–Selenium combination on Cadmium–induced damage in rat ovaries
dc.title.alternativeEfectos del extracto de Astragalus microcephalus y la combinación de vitamina E y Selenio sobre el daño tisular inducido por Cadmio en ovarios de rata
dc.typeArticle

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