Predicting Response to Androgen Deprivation Therapy and Resistance to Castration in Metastatic Prostate Cancer

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dc.contributor.authorÖztürk, Abuzer
dc.contributor.authorErgin, İsmail Emre
dc.contributor.authorAsdemir, Aydemir
dc.contributor.authorSaygın, Hüseyin
dc.date.accessioned2024-10-26T17:44:05Z
dc.date.available2024-10-26T17:44:05Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: We sought to identify predictive factors affecting time to castration resistance in metastatic prostate cancer patients receiving androgen deprivation therapy (ADT). Materials and Methods: We retrospectively evaluated 47 patients who received ADT with the diagnosis of metastatic prostate cancer. The patients\" age, International Society of Urological Pathology (ISUP) scores, baseline prostate specific antigen (PSA), alkaline phosphatase (ALP) value, prostate-specific membrane antigen (PSMA) tracer expression, represented by the maximum standardised uptake value (SUV max) at diagnosis, nadir PSA value, and time to resistance to ADT were recorded. Results: All patients included in the study were resistant to treatment with ADT. The mean age of the patients was 70.81 ± 1.15 years. The mean time to develop resistance to treatment after castration was 31.51 ± 4.9 months. In the correlation analysis, a significant negative correlation was detected between PSA, nadir PSA values and time to treatment resistance. The relationship between the SUVmax value of the primary prostate lesion, ALP value at the time of diagnosis and time to response to ADT developed was not significant. Conclusion: We found PSA values at diagnosis and nadir PSA values during follow-up to be predictive factors of treatment resistance in metastatic prostate cancer patients receiving ADT.
dc.identifier.doi10.5505/GJU.2024.54227
dc.identifier.endpage88
dc.identifier.issn2757-7163
dc.identifier.issue3
dc.identifier.startpage83
dc.identifier.trdizinid1265489
dc.identifier.urihttps://doi.org/10.5505/GJU.2024.54227
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1265489
dc.identifier.urihttps://hdl.handle.net/20.500.12418/25111
dc.identifier.volume4
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofGrand journal of urology (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titlePredicting Response to Androgen Deprivation Therapy and Resistance to Castration in Metastatic Prostate Cancer
dc.typeArticle

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