The effects of acute phase reactants and lesion size on functional outcome in stroke patients

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dc.contributor.authorTaş, Ayşenur
dc.contributor.authorKaptano?lu, Ece
dc.contributor.authorYilmaz, Kerim
dc.contributor.authorAkyüz, Aytekin
dc.contributor.authorBolayir, Ertu?rul
dc.contributor.authorTopaktaş, Suat
dc.date.accessioned2024-10-26T17:54:17Z
dc.date.available2024-10-26T17:54:17Z
dc.date.issued2004
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractLesion size and acute phase reactants have been claimed to predict the prognosis in stroke, recently. However, there are contradictory results in the literature. The aim of this study was to evaluate the relationship between the lesion size, acute phase reactants, and early functional outcome after ischemic stroke. In 64 patients with acute ischemic stroke, serum C-reactive protein, fibrinogen and ceruloplasmin levels were studied in the first 24 hours of the event. All patients underwent brain scanning with tomography. Functional status of the patients were evaluated with Barthel Index in the first 24 hours and after 3 months. There was a positive correlation between the 3rd month and 1st day Barthel Index, whereas there was a negative correlation between the 3rd month Barthel Index and C-reactive protein, ceruloplasmin, lesion size and age. There was also a positive correlation between the C-reactive protein level and the lesion size (p<0.05). In the dependent patients according to the 3rd month Barthel Index results, the acute phase reactants, lesion size, and age were significantly greater and the 1st day Barthel score was significatly lower than the independent group (p<0.001, Mann Whitney U). When 3rd month Barthel Index was used as final outcome (as dependent and independent groups), multiple logistic regression analysis identified ceruloplasmin (OR, 4,8; 95% CI, between 24,04 and 9,72; p=0,029) and lesion size (OR, 2,7; 95% CI, between 1, 17 and 6.34; p=0,019) as independent predictors of outcome. In conclusion, lesion size and ceruloplasmin may be accepted as indicators of short-term prognosis in patients with ischemic stroke.
dc.identifier.endpage20
dc.identifier.issn1302-0234
dc.identifier.issue4
dc.identifier.scopus2-s2.0-4644268600
dc.identifier.scopusqualityN/A
dc.identifier.startpage17
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27084
dc.identifier.volume50
dc.indekslendigikaynakScopus
dc.language.isotr
dc.relation.ispartofTurkiye Fiziksel Tip ve Rehabilitasyon Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcute phase reactants; Ceruloplasmin; Lesion size; Stroke
dc.titleThe effects of acute phase reactants and lesion size on functional outcome in stroke patients
dc.title.alternativeAkut Faz Reaktanlari ve Lezyon Büyüklü?ü nün ? Inmeli Hastalarda Fonksiyonel Prognoza Etkileri
dc.typeArticle

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