Association of soluble ST2 Level with 6-month Mortality and/or Recurrent Cardiovascular-Related Hospitalization in Pulmonary Embolism

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dc.authoridYilmaz, Mehmet Birhan/0000-0002-8169-8628
dc.contributor.authorGunes, Hakan
dc.contributor.authorGunes, Handan
dc.contributor.authorDagli, Musa
dc.contributor.authorKirisci, Mehmet
dc.contributor.authorOzbek, Meryem
dc.contributor.authorAtilla, Nurhan
dc.contributor.authorYilmaz, Mehmet Birhan
dc.date.accessioned2024-10-26T18:09:37Z
dc.date.available2024-10-26T18:09:37Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground: The association of soluble suppression of tumorigenesis-2 (sST2) levels with prognosis in pulmonary embolism (PE) is unknown. Objective: This study aimed to investigate the relationship between sST2 levels in patients with acute PE and 6 -month mortality and recurrent hospitalizations. Methods: This prospective study included 100 patients with acute PE. Patients were classified into two groups according to 6 -month mortality and the presence of recurrent Cardiovascular -Related hospitalizations. Two groups were compared. A p -value of 0.05 was considered statistically significant. Results: Soluble ST2 levels were significantly higher in the group with mortality and recurrent hospitalizations. (138.6 ng/mL (56.7-236.8) vs. 38 ng/mL (26.3-75.4); p<0.001) The best cut-off threshold for sST2 levels in the prediction of a composite outcome of 6 -month mortality and/or recurrent Cardiovascular -Related hospitalization was found to be >89.9 with a specificity of 90.6% and a sensitivity of 65.2%, according to the receiver operating characteristic curve (area under the curve = 0.798; 95% CI, 0.705-0.891; p <0.0001). After adjusting for confounding factors that were either statistically significant in the univariate analysis or for the variables correlated with the sST2 levels, sST2 level (OR = 1.019, 95% CI: 1.009-1.028, p 0.001) and C -reactive protein (CRP ) (OR = 1.010, 95% CI: 1.001-1.021, p = 0.046) continued to be significant predictors of 6 -month mortality and/or recurrent Cardiovascular -Related hospitalization in the multiple logistic regression model via backward stepwise method. Conclusion: Soluble ST2 level seems to be a biomarker to predict 6 -month mortality and/or recurrent CardiovascularRelated hospitalization in patients with acute PE.
dc.identifier.doi10.36660/abc.20230040
dc.identifier.issn0066-782X
dc.identifier.issn1678-4170
dc.identifier.issue2
dc.identifier.pmid38422305
dc.identifier.urihttps://doi.org/10.36660/abc.20230040
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30173
dc.identifier.volume121
dc.identifier.wosWOS:001179117400001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherArquivos Brasileiros Cardiologia
dc.relation.ispartofArquivos Brasileiros De Cardiologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPulmonary Embolism
dc.subjectMortality
dc.subjectHospitalization
dc.titleAssociation of soluble ST2 Level with 6-month Mortality and/or Recurrent Cardiovascular-Related Hospitalization in Pulmonary Embolism
dc.typeArticle

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