The pharmacokinetics of sulpiride and its effect on sexual behaviours and LH concentrations in anestrous does (Capra hircus)

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dc.authoridCorum, Orhan/0000-0003-3168-2510
dc.authoridKIVRAK, MEHMET BUGRA/0000-0002-4772-874X
dc.contributor.authorYuksel, Murat
dc.contributor.authorCorum, Orhan
dc.contributor.authorKivrak, Mehmet Bugra
dc.contributor.authorCorum, Duygu Durna
dc.contributor.authorTurk, Erdinc
dc.contributor.authorTakci, Abdurrahman
dc.contributor.authorYardimci, Sara Busra
dc.date.accessioned2025-05-04T16:47:00Z
dc.date.available2025-05-04T16:47:00Z
dc.date.issued2025
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThe aim of this study was to investigate the pharmacokinetics of sulpiride and its effect on sexual behaviours and LH concentrations in anestrous does (Capra hircus). This study was carried out in two stages: pharmacokinetics (stage I) and effect on LH pulsatility, concentration, and estrus display (stage II). In the stage I, sulpiride was administered via intravenous (IV), intramuscular (IM), subcutaneous (SC) and oral routes to does at a dose of 0.6 mg/kg. In the stage II, sulpiride was administered intramuscularly at a dose of 0.6 mg/kg every 12 hours for 10 days. Plasma concentrations of sulpiride were measured using HPLC and pharmacokinetic parameters were calculated by non-compartmental analysis. LH concentrations were quantified using ELISA. The terminal elimination half-life, apparent volume of distribution, and total body clearance of sulpiride following IV administration were 1.76 h, 0.38 L/kg, and 0.15 L/h/kg, respectively. The peak plasma concentration of IM and SC administration was 1.39 and 0.83 mu g/mL at 0.53 and 0.78 h, respectively. The bioavailability of sulpiride was 103.30 % for the IM route and 72.21 % for the SC route. Sulpiride showed erratic and low absorption after oral administration. While LH concentrations decreased significantly after sulpiride administration, the LH plus frequency increased significantly. In conclusion, sulpiride with distinctive effect on LH pulse frequency has the potential to be used in protocols for hastening cyclicity. However, more studies are needed on the use of sulpiride in estrus induction protocols.
dc.description.sponsorshipCoordination of Scientific Research Projects, University of Hatay Mustafa Kemal, Turkiye [20.M.047]
dc.description.sponsorshipWe would like to thank Assoc. Prof. Dr. Ibrahim Ozan Tekeli, who lost his life in the earthquake that occurred in Hatay/Tuerkiye on February 6, 2023, for his contributions in the experimental phase of the study. We remember him and his daughters Nefes and Eylul with respect. This study was supported by The Coordination of Scientific Research Projects, University of Hatay Mustafa Kemal, Turkiye (Project No. 20.M.047) .
dc.identifier.doi10.1016/j.smallrumres.2025.107442
dc.identifier.issn0921-4488
dc.identifier.issn1879-0941
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.smallrumres.2025.107442
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35448
dc.identifier.volume244
dc.identifier.wosWOS:001414035100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofSmall Ruminant Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250504
dc.subjectAnestrous goat
dc.subjectLH
dc.subjectPharmacokinetics
dc.subjectSulpiride
dc.titleThe pharmacokinetics of sulpiride and its effect on sexual behaviours and LH concentrations in anestrous does (Capra hircus)
dc.typeArticle

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